Surface Modification of Cisplatin-Complexed Gold Nanoparticles and Its Influence on Colloidal Stability, Drug Loading, and Drug Release

Cisplatin-complexed gold nanoparticles (PtII–AuNP) provide a promising strategy for chemo-radiation-based anticancer drugs. Effective design of such platforms necessitates reliable assessment of surface engineering on a quantitative basis and its influence on drug payload, stability, and release. In...

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Bibliographic Details
Published in:Langmuir 2018-01, Vol.34 (1), p.154-163
Main Authors: Tan, Jiaojie, Cho, Tae Joon, Tsai, De-Hao, Liu, Jingyu, Pettibone, John M, You, Rian, Hackley, Vincent A, Zachariah, Michael R
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Cisplatin - chemistry
Colloids - chemistry
Dendrimers - chemistry
Drug Liberation
Gold - chemistry
Hydrogen-Ion Concentration
Metal Nanoparticles - chemistry
Molecular Weight
Particle Size
Polyethylene Glycols - chemistry
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Summary:Cisplatin-complexed gold nanoparticles (PtII–AuNP) provide a promising strategy for chemo-radiation-based anticancer drugs. Effective design of such platforms necessitates reliable assessment of surface engineering on a quantitative basis and its influence on drug payload, stability, and release. In this paper, poly­(ethylene glycol) (PEG)-stabilized PtII–AuNP was synthesized as a model antitumor drug platform, where PtII is attached via a carboxyl-terminated dendron ligand. Surface modification by PEG and its influence on drug loading, colloidal stability, and drug release were assessed. Complexation with PtII significantly degrades colloidal stability of the conjugate; however, PEGylation provides substantial improvement of stability in conjunction with an insignificant trade-off in drug loading capacity compared with the non-PEGylated control (
ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.7b02354