Noncoding RNAs in the Regulation of Pluripotency and Reprogramming

Pluripotent stem cells have great potential for developmental biology and regenerative medicine. Embryonic stem cells, which are obtained from blastocysts, and induced pluripotent stem cells, which are generated by the reprogramming of somatic cells, are two main types of pluripotent cells. It is im...

Full description

Saved in:
Bibliographic Details
Published in:Stem cell reviews and reports 2018-02, Vol.14 (1), p.58-70
Main Authors: Sherstyuk, Vladimir V, Medvedev, Sergey P, Zakian, Suren M
Format: Article
Language:English
Subjects:
Animals
Blastocysts
Cell Differentiation - genetics
Cell Differentiation - physiology
Cellular Reprogramming - genetics
Cellular Reprogramming - physiology
Developmental biology
Embryo cells
Genome editing
Genomes
Humans
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Non-coding RNA
Pluripotency
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Regenerative medicine
Regulation
RNA, Untranslated - genetics
RNA, Untranslated - physiology
Somatic cells
Stem cells
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pluripotent stem cells have great potential for developmental biology and regenerative medicine. Embryonic stem cells, which are obtained from blastocysts, and induced pluripotent stem cells, which are generated by the reprogramming of somatic cells, are two main types of pluripotent cells. It is important to understand the regulatory network that controls the pluripotency state and reprogramming process. Various types of noncoding RNAs (ncRNAs) have emerged as substantial components of regulatory networks. The most studied class of ncRNAs in the context of pluripotency and reprogramming is microRNAs (miRNAs). In addition to canonical microRNAs, other types of small RNAs with miRNA-like function are expressed in PSCs. Another class of ncRNAs, long ncRNAs, are also involved in pluripotency and reprogramming regulation. Thousands of ncRNAs have been annotated to date, and a significant number of the molecules do not have known function. In this review, we briefly summarized recent advances in this field and described existing genome-editing approaches to study ncRNA functions.
ISSN:2629-3269
2629-3277
DOI:10.1007/s12015-017-9782-9