Is subchondral bone cyst formation in non-load-bearing region of osteoarthritic knee a vascular problem?

Subchondral bone cyst is common in the progressive knee osteoarthritis yet its underlying mechanism remains unclear. In addition to the existing theories such as synovial fluid influx and mechanical contusion, we identified the potential link between vascular pathology and osteoarthritic bone pathol...

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Bibliographic Details
Published in:Medical hypotheses 2017-11, Vol.109, p.80-83
Main Authors: Chan, Pok Man Boris, Wen, Chunyi, Yang, Wai Ching, Yan, Chunhoi, Chiu, KwongYuen
Format: Article
Language:English
Subjects:
Aged
Biomechanical Phenomena
Blood Pressure
Bone Cysts - complications
Bone Cysts - physiopathology
Cartilage, Articular - pathology
Disease Progression
Female
Humans
Knee
Knee Joint - physiopathology
Male
Middle Aged
Osteoarthritis, Knee - complications
Osteoarthritis, Knee - physiopathology
Risk Factors
Synovial Fluid
Vascular Diseases - complications
Vascular Diseases - physiopathology
Weight-Bearing
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Summary:Subchondral bone cyst is common in the progressive knee osteoarthritis yet its underlying mechanism remains unclear. In addition to the existing theories such as synovial fluid influx and mechanical contusion, we identified the potential link between vascular pathology and osteoarthritic bone pathologies including cystic lesion formation, particularly in the non-load-bearing region. This new hypothesis for SBC formation in non-load-bearing region for knee, which cannot be explained by the existing theories, will provide us a new angle to understand the pathomechanism and pathophysiology of subchondral bone disturbance in osteoarthritis in addition to the classical biomechanical overloading theories. It might guide us to develop a novel diagnostic and therapeutic approach to treat progressive osteoarthritis via targeting vascular pathology.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2017.09.027