Clinical study on Yishen Qufeng Shengshi Recipe (益肾祛风胜湿方) for glomerular proteinuria patients: A randomized controlled trial

• Published in: Chinese journal of integrative medicine 2018, Vol.24 (1), p.10-15
• Main Authors: Dai, Qin, Zhang, Pei-qing, Wang, Xiao-qin, Nie, Li-fang, Fu, Xiao-jun, Peng, Wen, Wang, Yi, Li, Jun, Bi, Yue-ping, Mi, Xiu-hua, Yuan, Min, He, Li-qun
• Format: Article
• Language: English
• Subjects: Drugs, Chinese Herbal - adverse effects; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Female; Humans; Kidney Glomerulus - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Proteinuria - drug therapy
• ISSN: 1672-0415; 1993-0402
• DOI: 10.1007/s11655-017-2908-8

Objective To explore the therapeutic effect of Yishen Qufeng Shengshi Recipe (益肾祛风胜湿方, YQSR) in patients with glomerular proteinuria Methods A total of 145 patients with glomerular proteinuria were selected and randomly assigned to the treatment group (108 cases) and the control group (37 cases) according to a random number table in a ratio of 3:1. All patients received conventional and symptomatic treatment. In addition, patients in the treatment and control groups were given YQSR (200 mL, twice per day, orally) and losartan (50 mg/d orally), respectively for 6 months. The 24-h urine protein quantity, blood urea nitrogen, and serum creatinine in the two groups were measured at multiple time points before and after treatment. Results At the end of the study, 5 cases were lost to follow-up in the treatment group and 1 in the control group. Finally, the statistical data included 103 cases in the treatment group and 36 cases in the control group. The total effectiveness after 2, 4, and 6 months was 81.6% (84/103), 87.4% (90/103), and 92.2% (95/103), respectively, in the treatment group and 47.2% (17/36), 55.6% (20/36), and 61.1% (22/36), respectively, in the control group, with significant difference between the two groups ( P