Autophagy and Inflammation

The cellular degradative pathway of autophagy has a fundamental role in immunity. Here, we review the function of autophagy and autophagy proteins in inflammation. We discuss how the autophagy machinery controls the burden of infectious agents while simultaneously limiting inflammatory pathologies,...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of immunology 2018-04, Vol.36 (1), p.73-101
Main Authors: Matsuzawa-Ishimoto, Yu, Hwang, Seungmin, Cadwell, Ken
Format: Article
Language:English
Subjects:
autoimmune disease
autophagy
infectious disease
inflammation
inflammatory bowel disease
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The cellular degradative pathway of autophagy has a fundamental role in immunity. Here, we review the function of autophagy and autophagy proteins in inflammation. We discuss how the autophagy machinery controls the burden of infectious agents while simultaneously limiting inflammatory pathologies, which often involves processes that are distinct from conventional autophagy. Among the newly emerging processes we describe are LC3-associated phagocytosis and targeting by autophagy proteins, both of which require many of the same proteins that mediate conventional autophagy. We also discuss how autophagy contributes to differentiation of myeloid and lymphoid cell types, coordinates multicellular immunity, and facilitates memory responses. Together, these functions establish an intimate link between autophagy, mucosal immunity, and chronic inflammatory diseases. Finally, we offer our perspective on current challenges and barriers to translation.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev-immunol-042617-053253