Loading…

Prenatal TVOCs exposure negatively influences postnatal neurobehavioral development

Prenatal exposure to volatile organic compounds may restrict fetal development and adversely influence infants' life. Therefore, we investigated the relationship between prenatal exposure to total volatile organic compounds (TVOC) and postnatal neurobehavioral development. A subsample of 383 pr...

Full description

Saved in:
Bibliographic Details
Published in:The Science of the total environment 2018-03, Vol.618, p.977-981
Main Authors: Chang, Moonhee, Lee, Dongheon, Park, Hyesook, Ha, Mina, Hong, Yun-Chul, Kim, Yangho, Kim, Boong-Nyun, Kim, Yeni, Lim, Youn-Hee, Ha, Eun-Hee
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prenatal exposure to volatile organic compounds may restrict fetal development and adversely influence infants' life. Therefore, we investigated the relationship between prenatal exposure to total volatile organic compounds (TVOC) and postnatal neurobehavioral development. A subsample of 383 pregnant participants was chosen from the prospective birth cohort study of Mother and Children’s Environmental Health Study; MOCEH (N=1,751) from three regions of the Republic of Korea (Seoul, Cheon-an, and Ulsan). Participants were enrolled during their first trimester with informed consent. We investigated maternal characteristics including socio-economic and obstetrical history using questionnaires. An environmental hygienist measured participating mothers' personal TVOC exposure using passive samplers during pregnancy. Participants visited the research center at 6, 12, 24 and 36 months. At each visit, questionnaires about infantile environment and health conditions were answered and a neurobehavioral test (BSID-II) was conducted by certified investigators. We conducted multiple general linear and mixed model analyses to investigate the relationship between TVOC and infantile neurobehavioral development (SAS 9.3). Mean prenatal TVOC exposure was 284.2μg/m3. In longitudinal analyses on infantile neurobehavioral development, adjusted mean psychomotor development index and mental developmental index scores in high TVOC exposure group (cut off at Q3: 374.0 ug/m3) were 3 points lower than the low exposure group. Results suggested exposure to higher TVOC during the fetal period may adversely influence neurobehavioral development in the early life stage. •We examined the relationship between prenatal TVOC exposure and early children's neurodevelopment at 6=36 months of age.•High TVOC exposure during the fetal period may negatively influence neurobehavioral development•Need to pay careful attention to reduce TVOC exposure during pregnancy [Display omitted]
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2017.09.046