Understanding the role of mammalian sterile 20-like kinase 1 (MST1) in cardiovascular disorders

Hippo signaling is a conserved pathway and plays important roles in controlling cell proliferation and differentiation. As a critical component of the Hippo pathway in mammals, mammalian sterile 20-like kinase 1 (MST1) participates in cell apoptosis and cell proliferation. Yes-associated protein (YA...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2018-01, Vol.114, p.141-149
Main Authors: Yang, Yang, Wang, Haichang, Ma, Zhiqiang, Hu, Wei, Sun, Dongdong
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Autophagy
Cardiovascular Diseases - enzymology
Cardiovascular Diseases - pathology
Cardiovascular disorders
Cardiovascular System - enzymology
Cardiovascular System - pathology
Humans
Mammalian sterile 20-like kinase 1
Mammals - metabolism
Protein-Serine-Threonine Kinases - metabolism
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Summary:Hippo signaling is a conserved pathway and plays important roles in controlling cell proliferation and differentiation. As a critical component of the Hippo pathway in mammals, mammalian sterile 20-like kinase 1 (MST1) participates in cell apoptosis and cell proliferation. Yes-associated protein (YAP) acts as a downstream transcriptional co-activator of MST1. MST1 is present in heart tissue and helps determine the fate of cardiomyocytes by regulating the balance between autophagy and apoptosis. Recent studies showed MST1 signaling is an essential participant in many cardiovascular disorders, including aortic dissection, aortic aneurysm, atherosclerosis, myocardial ischemic injury, and cardiomyopathy. Previous studies have summarized the roles of MST1 in cardiovascular development. In this review, we focused on the roles of MST1 signaling in cardiovascular disorders. •MST1 signaling regulates the balance between autophagy and apoptosis in the cardiovascular system.•Beclin1 serves as a bridge between the interesting effects of MST1 on apoptosis and the effects of this protein on autophagy.•MST1 expression is regulated by FOXO3 in the heart, whereas, MST1 also activates the FOXO protein family.•MST1 signaling is an essential participant in many cardiovascular disorders.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2017.11.010