Correlation between phosphorylation level of a hippocampal 86kDa protein and extinction of a behaviour in a model of Wernicke-Korsakoff syndrome

The effects of chronic ethanol and thiamine deficiency, alone or associated, on hippocampal protein phosphorylation profiles ranging in molecular weight from 30 to 250kDa molecular weight, in stimulated (high K(+) concentration) and unstimulated (basal) conditions were investigated. These treatments...

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Published in:Behavioural brain research 2007-06, Vol.180 (1), p.102-106
Main Authors: Pires, Rita G W, Pereira, Sílvia R C, Carvalho, Fabiana M, Oliveira-Silva, Ieda F, Ferraz, Vany P, Ribeiro, Angela M
Format: Article
Language:English
Subjects:
Animals
Central Nervous System Depressants - pharmacology
Disease Models, Animal
Ethanol - pharmacology
Extinction, Psychological - physiology
Hippocampus - metabolism
Korsakoff Syndrome - metabolism
Male
Nerve Tissue Proteins - metabolism
Phosphorylation
Rats
Rats, Wistar
Thiamine Deficiency - metabolism
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Summary:The effects of chronic ethanol and thiamine deficiency, alone or associated, on hippocampal protein phosphorylation profiles ranging in molecular weight from 30 to 250kDa molecular weight, in stimulated (high K(+) concentration) and unstimulated (basal) conditions were investigated. These treatments significantly changed the phosphorylation level of an 86kDa phosphoprotein. Thiamine deficiency, but not chronic ethanol, induced a decrease in a behavioural extinction index, which is significantly correlated to the phosphorylation level of the p86 protein. These data add to and extend previous findings by our laboratory implicating the involvement of hippocampal neurotransmission components in extinction of a behaviour which involves learning of environmental spatial cues.
ISSN:0166-4328
DOI:10.1016/j.bbr.2007.02.017