Urinalysis for the diagnosis of glomerulonephritis: role of dysmorphic red blood cells

Dysmorphic red blood cells (dRBCs) on urine microscopy have been associated with glomerulonephritis (GN). We assessed the prevalence and ability of dRBCs to differentiate GN from other kidney diseases. Adult patients with kidney biopsy performed between 2012 and 2015 at a single center who had a con...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2018-08, Vol.33 (8), p.1397-1403
Main Authors: Hamadah, Abdurrahman M, Gharaibeh, Kamel, Mara, Kristin C, Thompson, Katherine A, Lieske, John C, Said, Samar, Nasr, Samih H, Leung, Nelson
Format: Article
Language:English
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Summary:Dysmorphic red blood cells (dRBCs) on urine microscopy have been associated with glomerulonephritis (GN). We assessed the prevalence and ability of dRBCs to differentiate GN from other kidney diseases. Adult patients with kidney biopsy performed between 2012 and 2015 at a single center who had a concurrent urinalysis were retrospectively studied. The association of ≥25% dRBCs with the presence of glomerular pathology was assessed. Univariate and multivariate logistic regression were performed on significantly associated variables. The mean age of the 482 eligible subjects was 55 years and 47.7% were female. Overall, 173 (35.9%) had 10 versus ≤10 (P 10 RBCs/high-power field) and proteinuria performed just as well as dRBCs plus proteinuria to predict underlying GN. A model based on the degree of hematuria and proteinuria found on urinalysis was able to predict the presence of GN.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfx274