Effect of the selective dopamine D sub(3) receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain

SB-277011-A is a dopamine D sub(3) receptor antagonist that exhibits over 100-fold selectivity over dopamine D sub(2) receptors and a broad spectrum of other receptor, ion channels, and enzymes. We employed c-Fos immunohistochemistry to characterise the functional neuroanatomical effects of acute ad...

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Bibliographic Details
Published in:Brain research 2007-05, Vol.1149, p.50-57
Main Authors: Southam, E, Lloyd, A, Jennings, CA, Cluderay, JE, Cilia, J, Gartlon, JE, Jones, DNC
Format: Article
Language:English
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Summary:SB-277011-A is a dopamine D sub(3) receptor antagonist that exhibits over 100-fold selectivity over dopamine D sub(2) receptors and a broad spectrum of other receptor, ion channels, and enzymes. We employed c-Fos immunohistochemistry to characterise the functional neuroanatomical effects of acute administration of SB-277011-A and observed a time-dependent increase in the density of c-Fos-like positive nuclei in rat forebrain with maximal effects observed 2 h post-dose. The relative influence of the different brain regions on the overall effect of SB-277011-A was ranked by partial least squares discriminant analysis loadings plot which indicated that sites within the nucleus accumbens exerted the greatest influence on the separation of the vehicle and SB-277011-A treatment groups. At the 2 h time-point, c-Fos-like expression was shown to be significantly elevated (p
ISSN:0006-8993
DOI:10.1016/j.brainres.2007.02.051