Magic angle spinning NMR below 6 K with a computational fluid dynamics analysis of fluid flow and temperature gradients

[Display omitted] •Magic angle spinning (MAS) with a sample temperature 500. Computer assisted design (CAD) and finite element analysis were employed in both the design and diagnostic stages of this cryogenic MAS technology development. Computational fluid dynamics (CFD) models describing temperatur...

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Bibliographic Details
Published in:Journal of magnetic resonance (1997) 2018-01, Vol.286, p.1-9
Main Authors: Sesti, Erika L., Alaniva, Nicholas, Rand, Peter W., Choi, Eric J., Albert, Brice J., Saliba, Edward P., Scott, Faith J., Barnes, Alexander B.
Format: Article
Language:English
Subjects:
Computational fluid dynamics
Cryogenic magic angle spinning
Dynamic nuclear polarization
Electron decoupling
Hyperfine decoupling
Instrumentation
Pulsed DNP
Time-domain DNP
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Summary:[Display omitted] •Magic angle spinning (MAS) with a sample temperature 500. Computer assisted design (CAD) and finite element analysis were employed in both the design and diagnostic stages of this cryogenic MAS technology development. Computational fluid dynamics (CFD) models describing temperature gradients and fluid flow are presented. The CFD models bearing and drive gas maintained at 100 K, while a colder helium variable temperature fluid stream cools the center of a zirconia rotor. Results from the CFD were used to optimize the helium exhaust path and determine the sample temperature. This novel cryogenic experimental platform will be integrated with pulsed dynamic nuclear polarization and electron decoupling to interrogate biomolecular structure within intact human cells.
ISSN:1090-7807
1096-0856
DOI:10.1016/j.jmr.2017.11.002