Laboratory diagnosis of SARS

The emergence of new viral infections of man requires the development of robust diagnostic tests that can be applied in the differential diagnosis of acute illness, or to determine past exposure, so as to establish the true burden of disease. Since the recognition in April 2003 of the severe acute r...

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Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2004-07, Vol.359 (1447), p.1083-1089
Main Authors: Bermingham, A., Heinen, P., Iturriza-Gómara, M., Gray, J., Appleton, H., Zambon, M. C.
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Viral - immunology
Coronavirus
Diseases
Humans
Immune Response
Immunoassay - methods
Infections
Laboratory Diagnosis
Molecular Probe Techniques
Reverse transcriptase polymerase chain reaction
RT-PCR
SARS
SARS coronavirus
SARS virus
SARS Virus - genetics
SARS Virus - immunology
SARS Virus - physiology
Serologic Tests - methods
Severe acute respiratory syndrome
Severe Acute Respiratory Syndrome - diagnosis
Severe Acute Respiratory Syndrome - immunology
Symptoms
Viruses
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Summary:The emergence of new viral infections of man requires the development of robust diagnostic tests that can be applied in the differential diagnosis of acute illness, or to determine past exposure, so as to establish the true burden of disease. Since the recognition in April 2003 of the severe acute respiratory syndrome coronavirus (SARS-CoV) as the causative agent of severe acute respiratory syndrome (SARS), enormous efforts have been applied to develop molecular and serological tests for SARS which can assist rapid detection of cases, accurate diagnosis of illness and the application of control measures. International progress in the laboratory diagnosis of SARS-CoV infection during acute illness has led to internationally agreed World Health Organization criteria for the confirmation of SARS. Developments in the dissection of the human immune response to SARS indicate that serological tests on convalescent sera are essential to confirm SARS infection, given the sub-optimal predictive value of molecular detection tests performed during acute SARS illness.
ISSN:0962-8436
1471-2970
DOI:10.1098/rstb.2004.1493