Oral contraceptives positively affect mood in healthy PMS-free women: A longitudinal study

Menstrual cycle phase and oral contraceptives (OC) use influence mood and cognition and these effects may be moderated by the mineralocorticoid receptor (MR) genotype. The effect of menstrual cycle phase on mood may be increased if participants know that this is the focus of study. We assessed aspec...

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Bibliographic Details
Published in:Journal of psychosomatic research 2017-12, Vol.103, p.119-126
Main Authors: Hamstra, Danielle A., de Kloet, E. Ronald, de Rover, Mischa, Van der Does, Willem
Format: Article
Language:English
Subjects:
Adult
Affect - drug effects
Birth control
Cognition
Contraceptives, Oral - pharmacology
Contraceptives, Oral - therapeutic use
Emotions
Female
Genotypes
Health status
Healthy Volunteers
Humans
Lability
Longitudinal Studies
Masking
Menopausal women
Menstrual cycle
Menstrual Cycle - psychology
Menstruation
Mental depression
Mental health
Mineralocorticoid receptor haplotype
Mood
Negative emotions
Neurosis
Neuroticism
Oral contraceptives
Personality tests
Positive emotions
Prospective Studies
Questionnaires
Reproductive depression
Variability
Women
Young Adult
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Summary:Menstrual cycle phase and oral contraceptives (OC) use influence mood and cognition and these effects may be moderated by the mineralocorticoid receptor (MR) genotype. The effect of menstrual cycle phase on mood may be increased if participants know that this is the focus of study. We assessed aspects associated with reproductive depression such as mood, interpersonal sensitivity, affect lability and depressive cognitions in MR-genotyped OC-users and naturally cycling (NC) women in a carefully masked design. A homogenous sample of healthy, PMS-free, pre-menopausal MR-genotyped women (n=92) completed online questionnaires eight times during two consecutive cycles. The masking of the research question was successful. OC-users did not differ significantly from NC women in positive and negative affect at the time of assessment, personality characteristics (e.g. neuroticism) or mental and physical health. Both groups reported more shifts in anger in the first cycle week (p
ISSN:0022-3999
1879-1360
DOI:10.1016/j.jpsychores.2017.10.011