Endometrial cancer evolution: new molecular-biologic types and hormonal-metabolic shifts

The question hidden in the title of this manuscript (whether the topic develops or remains constant) is important for all areas of science. It is also a serious problem for endometrial cancer (EC) study. In recent times the incidence of EC gradually increases in parallel with obesity epidemics. The...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2017-12, Vol.13 (28), p.2593-2605
Main Authors: Berstein, Lev M, Berlev, Igor V, Baltrukova, Alexandra N
Format: Article
Language:English
Subjects:
Age
Animals
Biological Evolution
Breast cancer
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
changes with generations
Comorbidity
disease risk and prevention
Disease Susceptibility
endocrine
Endometrial cancer
Endometrial Neoplasms - diagnosis
Endometrial Neoplasms - epidemiology
Endometrial Neoplasms - etiology
Endometrial Neoplasms - metabolism
Female
Females
Gynecology
Health risk assessment
Hispanic people
Hormones - metabolism
Humans
Medical screening
metabolic and immune factors
Metabolism
Morphology
Mutation
Neoplasm Grading
new types
Ovarian cancer
Patients
Phenotype
Population
Population Surveillance
renovation of views
Risk Factors
Studies
Systematic review
Tumors
Womens health
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Description
Summary:The question hidden in the title of this manuscript (whether the topic develops or remains constant) is important for all areas of science. It is also a serious problem for endometrial cancer (EC) study. In recent times the incidence of EC gradually increases in parallel with obesity epidemics. The main point of this review was evaluation of changes in EC area in last few decades, which are not only seen in tumor incidence, but also in its biology, hormonal-metabolic characteristics of patients and in the ratio of risk and anti-risk factors. One can hope that data accumulated recently and summarized here under the notion of EC evolution will find its use for advancement of EC prevention and treatment.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2017-0217