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Gastric emptying of different meal volumes of identical composition in preterm infants: a time series analysis
Background Preterm infants’ meals typically progress to higher volumes over time. Knowledge of gastric emptying (GE) responses to differing meal volumes may inform enteral feeding management. We examined the effect of meal volume and composition on preterm GE. Methods Forty infants were studied at 3...
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| Published in: | Pediatric research 2018-04, Vol.83 (4), p.778-783 |
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| container_title | Pediatric research |
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| creator | Perrella, Sharon L Hepworth, Anna R Gridneva, Zoya Simmer, Karen N Hartmann, Peter E Geddes, Donna T |
| description | Background
Preterm infants’ meals typically progress to higher volumes over time. Knowledge of gastric emptying (GE) responses to differing meal volumes may inform enteral feeding management. We examined the effect of meal volume and composition on preterm GE.
Methods
Forty infants were studied at 33.3±1.4 (29.7–35.6) weeks postmenstrual age when fully enteral fed (target 150 ml/kg/day). Intraindividual comparisons of GE were made for paired meals of 100% and 75% prescribed volume and identical composition of mother’s own milk (
n
=21) and pasteurized donor human milk (
n
=19). Serial stomach ultrasound images were used to calculate gastric residual volumes (GRVs) and remaining meal proportions (% meal).
Results
GE was faster in the early postprandial period and slowed over time (
P |
| doi_str_mv | 10.1038/pr.2017.292 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1967863172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1967863172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-379ce486cb88c5213997a7c922169ef7b1cbc5e0b9c9e4a6316c1f099c74096d3</originalsourceid><addsrcrecordid>eNp9kc2LFDEQxYMo7rh68i4BL4L2WPnopONNFl2FBS96btKZ6iVLJ2mTtDD_vRlmVRDxlOTVr15VeIQ8Z7BnIIa3a95zYHrPDX9AdqwX0IGU-iHZAQjWCWOGC_KklDsAJvtBPiYX3DClhO53JF7bUrN3FMNajz7e0jTTg59nzBgrDWgX-iMtW8ByqvhDU71rokthTcVXnyL1ka4ZK-bQrrONtbyjllYfkBbMvrXaaJdj8eUpeTTbpeCz-_OSfPv44evVp-7my_Xnq_c3nZPM1E5o41AOyk3D4HrO2h-01c5wzpTBWU_MTa5HmIwzKK0STDk2gzFOSzDqIC7Jq7PvmtP3DUsdgy8Ol8VGTFsZmVF6aG2aN_TlX-hd2nLbt4xcCIB-AJD_pUBIrjQI06jXZ8rlVErGeVyzDzYfRwbjKaz2Hk9hjS2sRr-499ymgIff7K90GvDmDJRWireY_wz9l99PBAidag</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2034267039</pqid></control><display><type>article</type><title>Gastric emptying of different meal volumes of identical composition in preterm infants: a time series analysis</title><source>Springer Link</source><creator>Perrella, Sharon L ; Hepworth, Anna R ; Gridneva, Zoya ; Simmer, Karen N ; Hartmann, Peter E ; Geddes, Donna T</creator><creatorcontrib>Perrella, Sharon L ; Hepworth, Anna R ; Gridneva, Zoya ; Simmer, Karen N ; Hartmann, Peter E ; Geddes, Donna T</creatorcontrib><description>Background
Preterm infants’ meals typically progress to higher volumes over time. Knowledge of gastric emptying (GE) responses to differing meal volumes may inform enteral feeding management. We examined the effect of meal volume and composition on preterm GE.
Methods
Forty infants were studied at 33.3±1.4 (29.7–35.6) weeks postmenstrual age when fully enteral fed (target 150 ml/kg/day). Intraindividual comparisons of GE were made for paired meals of 100% and 75% prescribed volume and identical composition of mother’s own milk (
n
=21) and pasteurized donor human milk (
n
=19). Serial stomach ultrasound images were used to calculate gastric residual volumes (GRVs) and remaining meal proportions (% meal).
Results
GE was faster in the early postprandial period and slowed over time (
P
<0.001). Reduced volume meals had slower GE rates and lower GRV (
P
<0.001). Serial postprandial % meal was similar between reduced and full volume meals (
P
=0.41). Higher milk casein concentration was associated with slower GE (
P
=0.04). Complete gastric emptying (GRV=0 ml) was more common in infants fed at 3 h intervals compared with those fed every 2 h (
P
=0.002).
Conclusion
Early postprandial GE is more rapid for larger meal volumes. Stable preterm infants may tolerate feeding of a 3 h meal volume at shorter intervals.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2017.292</identifier><identifier>PMID: 29166375</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/4020 ; 692/700/1720/3185 ; 692/700/1720/3186 ; Animals ; Cattle ; Child Nutrition Sciences ; clinical-investigation ; Eating ; Enteral Nutrition - methods ; Female ; Gastric Emptying ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Linear Models ; Male ; Meals ; Medicine ; Medicine & Public Health ; Milk, Human ; Newborn babies ; Pediatric Surgery ; Pediatrics ; Portion Size ; Postprandial Period ; Premature babies ; Premature birth ; Stomach ; Stomach - diagnostic imaging ; Ultrasonography ; Western Australia ; Whey Proteins - metabolism</subject><ispartof>Pediatric research, 2018-04, Vol.83 (4), p.778-783</ispartof><rights>International Pediatric Research Foundation, Inc. 2018</rights><rights>Copyright Nature Publishing Group Apr 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-379ce486cb88c5213997a7c922169ef7b1cbc5e0b9c9e4a6316c1f099c74096d3</citedby><cites>FETCH-LOGICAL-c419t-379ce486cb88c5213997a7c922169ef7b1cbc5e0b9c9e4a6316c1f099c74096d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29166375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perrella, Sharon L</creatorcontrib><creatorcontrib>Hepworth, Anna R</creatorcontrib><creatorcontrib>Gridneva, Zoya</creatorcontrib><creatorcontrib>Simmer, Karen N</creatorcontrib><creatorcontrib>Hartmann, Peter E</creatorcontrib><creatorcontrib>Geddes, Donna T</creatorcontrib><title>Gastric emptying of different meal volumes of identical composition in preterm infants: a time series analysis</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Preterm infants’ meals typically progress to higher volumes over time. Knowledge of gastric emptying (GE) responses to differing meal volumes may inform enteral feeding management. We examined the effect of meal volume and composition on preterm GE.
Methods
Forty infants were studied at 33.3±1.4 (29.7–35.6) weeks postmenstrual age when fully enteral fed (target 150 ml/kg/day). Intraindividual comparisons of GE were made for paired meals of 100% and 75% prescribed volume and identical composition of mother’s own milk (
n
=21) and pasteurized donor human milk (
n
=19). Serial stomach ultrasound images were used to calculate gastric residual volumes (GRVs) and remaining meal proportions (% meal).
Results
GE was faster in the early postprandial period and slowed over time (
P
<0.001). Reduced volume meals had slower GE rates and lower GRV (
P
<0.001). Serial postprandial % meal was similar between reduced and full volume meals (
P
=0.41). Higher milk casein concentration was associated with slower GE (
P
=0.04). Complete gastric emptying (GRV=0 ml) was more common in infants fed at 3 h intervals compared with those fed every 2 h (
P
=0.002).
Conclusion
Early postprandial GE is more rapid for larger meal volumes. Stable preterm infants may tolerate feeding of a 3 h meal volume at shorter intervals.</description><subject>692/4020</subject><subject>692/700/1720/3185</subject><subject>692/700/1720/3186</subject><subject>Animals</subject><subject>Cattle</subject><subject>Child Nutrition Sciences</subject><subject>clinical-investigation</subject><subject>Eating</subject><subject>Enteral Nutrition - methods</subject><subject>Female</subject><subject>Gastric Emptying</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Linear Models</subject><subject>Male</subject><subject>Meals</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Milk, Human</subject><subject>Newborn babies</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Portion Size</subject><subject>Postprandial Period</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Stomach</subject><subject>Stomach - diagnostic imaging</subject><subject>Ultrasonography</subject><subject>Western Australia</subject><subject>Whey Proteins - metabolism</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kc2LFDEQxYMo7rh68i4BL4L2WPnopONNFl2FBS96btKZ6iVLJ2mTtDD_vRlmVRDxlOTVr15VeIQ8Z7BnIIa3a95zYHrPDX9AdqwX0IGU-iHZAQjWCWOGC_KklDsAJvtBPiYX3DClhO53JF7bUrN3FMNajz7e0jTTg59nzBgrDWgX-iMtW8ByqvhDU71rokthTcVXnyL1ka4ZK-bQrrONtbyjllYfkBbMvrXaaJdj8eUpeTTbpeCz-_OSfPv44evVp-7my_Xnq_c3nZPM1E5o41AOyk3D4HrO2h-01c5wzpTBWU_MTa5HmIwzKK0STDk2gzFOSzDqIC7Jq7PvmtP3DUsdgy8Ol8VGTFsZmVF6aG2aN_TlX-hd2nLbt4xcCIB-AJD_pUBIrjQI06jXZ8rlVErGeVyzDzYfRwbjKaz2Hk9hjS2sRr-499ymgIff7K90GvDmDJRWireY_wz9l99PBAidag</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Perrella, Sharon L</creator><creator>Hepworth, Anna R</creator><creator>Gridneva, Zoya</creator><creator>Simmer, Karen N</creator><creator>Hartmann, Peter E</creator><creator>Geddes, Donna T</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Gastric emptying of different meal volumes of identical composition in preterm infants: a time series analysis</title><author>Perrella, Sharon L ; Hepworth, Anna R ; Gridneva, Zoya ; Simmer, Karen N ; Hartmann, Peter E ; Geddes, Donna T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-379ce486cb88c5213997a7c922169ef7b1cbc5e0b9c9e4a6316c1f099c74096d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/4020</topic><topic>692/700/1720/3185</topic><topic>692/700/1720/3186</topic><topic>Animals</topic><topic>Cattle</topic><topic>Child Nutrition Sciences</topic><topic>clinical-investigation</topic><topic>Eating</topic><topic>Enteral Nutrition - methods</topic><topic>Female</topic><topic>Gastric Emptying</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Linear Models</topic><topic>Male</topic><topic>Meals</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Milk, Human</topic><topic>Newborn babies</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Portion Size</topic><topic>Postprandial Period</topic><topic>Premature babies</topic><topic>Premature birth</topic><topic>Stomach</topic><topic>Stomach - diagnostic imaging</topic><topic>Ultrasonography</topic><topic>Western Australia</topic><topic>Whey Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perrella, Sharon L</creatorcontrib><creatorcontrib>Hepworth, Anna R</creatorcontrib><creatorcontrib>Gridneva, Zoya</creatorcontrib><creatorcontrib>Simmer, Karen N</creatorcontrib><creatorcontrib>Hartmann, Peter E</creatorcontrib><creatorcontrib>Geddes, Donna T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perrella, Sharon L</au><au>Hepworth, Anna R</au><au>Gridneva, Zoya</au><au>Simmer, Karen N</au><au>Hartmann, Peter E</au><au>Geddes, Donna T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric emptying of different meal volumes of identical composition in preterm infants: a time series analysis</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>83</volume><issue>4</issue><spage>778</spage><epage>783</epage><pages>778-783</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Preterm infants’ meals typically progress to higher volumes over time. Knowledge of gastric emptying (GE) responses to differing meal volumes may inform enteral feeding management. We examined the effect of meal volume and composition on preterm GE.
Methods
Forty infants were studied at 33.3±1.4 (29.7–35.6) weeks postmenstrual age when fully enteral fed (target 150 ml/kg/day). Intraindividual comparisons of GE were made for paired meals of 100% and 75% prescribed volume and identical composition of mother’s own milk (
n
=21) and pasteurized donor human milk (
n
=19). Serial stomach ultrasound images were used to calculate gastric residual volumes (GRVs) and remaining meal proportions (% meal).
Results
GE was faster in the early postprandial period and slowed over time (
P
<0.001). Reduced volume meals had slower GE rates and lower GRV (
P
<0.001). Serial postprandial % meal was similar between reduced and full volume meals (
P
=0.41). Higher milk casein concentration was associated with slower GE (
P
=0.04). Complete gastric emptying (GRV=0 ml) was more common in infants fed at 3 h intervals compared with those fed every 2 h (
P
=0.002).
Conclusion
Early postprandial GE is more rapid for larger meal volumes. Stable preterm infants may tolerate feeding of a 3 h meal volume at shorter intervals.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>29166375</pmid><doi>10.1038/pr.2017.292</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2018-04, Vol.83 (4), p.778-783 |
| issn | 0031-3998 1530-0447 |
| language | eng |
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| source | Springer Link |
| subjects | 692/4020 692/700/1720/3185 692/700/1720/3186 Animals Cattle Child Nutrition Sciences clinical-investigation Eating Enteral Nutrition - methods Female Gastric Emptying Humans Infant Infant, Newborn Infant, Premature Linear Models Male Meals Medicine Medicine & Public Health Milk, Human Newborn babies Pediatric Surgery Pediatrics Portion Size Postprandial Period Premature babies Premature birth Stomach Stomach - diagnostic imaging Ultrasonography Western Australia Whey Proteins - metabolism |
| title | Gastric emptying of different meal volumes of identical composition in preterm infants: a time series analysis |
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