Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy

Reports of decreased serum 25-hydroxyvitamin D (25-OHD) and altered bone metabolism associated with antiepileptic drug (AED) treatment are inconsistent and predominantly restricted to adults. In this cross-sectional observational study, the aim was to evaluate the influence of AED treatment on vitam...

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Bibliographic Details
Published in:European journal of pediatrics 2008-12, Vol.167 (12), p.1369-1377
Main Authors: Nettekoven, Sina, Ströhle, Alexander, Trunz, Birgit, Wolters, Maike, Hoffmann, Susanne, Horn, Rüdiger, Steinert, Martin, Brabant, Georg, Lichtinghagen, Ralf, Welkoborsky, Hans-Jürgen, Tuxhorn, Ingrid, Hahn, Andreas
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Anticonvulsants - administration & dosage
Anticonvulsants - adverse effects
Biological and medical sciences
Biomarkers - blood
Bone Resorption - blood
Bone Resorption - chemically induced
Bone Resorption - prevention & control
Calcium - blood
Child
Collagen Type I - blood
Convulsions & seizures
Cross-Sectional Studies
Drug therapy
Endocrinology
Epilepsy
Epilepsy - blood
Epilepsy - drug therapy
Female
General aspects
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hospitals
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolism
Nervous system (semeiology, syndromes)
Neurology
Original Paper
Osteocalcin - blood
Otolaryngology
Parathyroid Hormone - blood
Pediatrics
Phosphatase
Surveys and Questionnaires
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - chemically induced
Vitamin D Deficiency - metabolism
Vitamin D Deficiency - prevention & control
Vitamin deficiency
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Description
Summary:Reports of decreased serum 25-hydroxyvitamin D (25-OHD) and altered bone metabolism associated with antiepileptic drug (AED) treatment are inconsistent and predominantly restricted to adults. In this cross-sectional observational study, the aim was to evaluate the influence of AED treatment on vitamin D status and markers of bone turnover in children with epilepsy. In 38 children taking AEDs and 44 healthy control subjects, blood samples were collected to determine the levels of serum 25-OHD, intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), bone alkaline phosphatase (BAP), osteocalcin (OC) and C terminal telopeptide of type I collagen (ICTP). More than 75% of the patients were vitamin D deficient (serum 25-OHD
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-008-0672-7