Proteomic evaluation of human umbilical cord tissue exposed to polybrominated diphenyl ethers in an e-waste recycling area

Parental exposure to polybrominated diphenyl ethers (PBDEs) is associated with adverse birth outcomes. This study aims to examine differentially-expressed protein profiles in umbilical cord tissue, derived from mothers exposed to PBDEs, and investigate candidate biomarkers to reveal the underlying m...

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Bibliographic Details
Published in:Environment international 2018-02, Vol.111, p.362-371
Main Authors: Li, Minghui, Huo, Xia, Pan, Yukui, Cai, Haoxing, Dai, Yifeng, Xu, Xijin
Format: Article
Language:English
Subjects:
Adult
Anthropometry
Apgar Score
China
E-waste
Electronic Waste - adverse effects
Environmental Monitoring
Enzyme-Linked Immunosorbent Assay
Female
Fetal Development - drug effects
Fetal growth
Gas Chromatography-Mass Spectrometry
Halogenated Diphenyl Ethers - toxicity
Humans
Infant, Newborn
PBDEs
Pregnancy
Prospective Studies
Proteome
Proteomics
Proteomics - methods
Recycling
Umbilical cord
Umbilical Cord - chemistry
Umbilical Cord - drug effects
Young Adult
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Summary:Parental exposure to polybrominated diphenyl ethers (PBDEs) is associated with adverse birth outcomes. This study aims to examine differentially-expressed protein profiles in umbilical cord tissue, derived from mothers exposed to PBDEs, and investigate candidate biomarkers to reveal the underlying molecular mechanisms. Umbilical cord samples were obtained from women residing in an electronic waste (e-waste) recycling area (Guiyu) and reference area (Haojiang) in China. The concentration of PBDEs in umbilical cord tissue was determined by gas chromatography and mass spectrometry (GC/MS). Isobaric tagging for relative and absolute quantification (iTRAQ)-based proteomic technology was conducted to analyze differentially-expressed protein profiles. The total PBDE concentration was approximately five-fold higher in umbilical cords from Guiyu than from Haojiang (median 71.92ng/g vs. 15.52ng/g lipid, P
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2017.09.016