Loading…
Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents
[Display omitted] Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample b...
Saved in:
| Published in: | Bioorganic chemistry 2018-02, Vol.76, p.113-129 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c362t-c6388b3daea44116225e14ca07c5da223617a1c9446800bb827b35668d99001b3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c362t-c6388b3daea44116225e14ca07c5da223617a1c9446800bb827b35668d99001b3 |
| container_end_page | 129 |
| container_issue | |
| container_start_page | 113 |
| container_title | Bioorganic chemistry |
| container_volume | 76 |
| creator | Wang, Meng Rakesh, K.P. Leng, Jing Fang, Wan-Yin Ravindar, L. Channe Gowda, D. Qin, Hua-Li |
| description | [Display omitted]
Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties. Synthetic amino acid/peptides based heterocyclic conjugates constitute a promising choice for the development of new, less toxic and safer conventional pharmaceutical drugs in the near future. In this review, we discuss and highlight the recent findings of the structural features that encourage biological applications of amino acid/peptides based conjugates. |
| doi_str_mv | 10.1016/j.bioorg.2017.11.007 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1968445022</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0045206817305096</els_id><sourcerecordid>1968445022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-c6388b3daea44116225e14ca07c5da223617a1c9446800bb827b35668d99001b3</originalsourceid><addsrcrecordid>eNp9kEFv1DAQhS0EotuFf4CQj1ySzjiOk3BAWlW0IFXi0p4tx57dekniYDuV-u_JaluOnGZG8948zcfYJ4QSAdXVsex9CPFQCsCmRCwBmjdsg9BBIVDAW7YBkHUhQLUX7DKlIwCibNR7diE6VB007Yb93o1-CtxY79LVTHP2jhK3YTouB5PJ8UfKFIN9tgOlr3zHcwgD34fI8yPxSJamzB090RDm8dSHPZ_COp720cy0ZG-5Oayr9IG925sh0ceXumUPN9_vr38Ud79uf17v7gpbKZELq6q27StnyEiJqISoCaU10NjaGSEqhY1B20mpWoC-b0XTV7VSreu69cW-2rIv57tzDH8WSlmPPlkaBjNRWJLGTrVS1rCe2jJ5ltoYUoq013P0o4nPGkGfMOujPmPWJ8waUa-YV9vnl4SlH8n9M71yXQXfzgJa_3zyFHWyniZLzq_MsnbB_z_hL-gSkJo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1968445022</pqid></control><display><type>article</type><title>Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents</title><source>ScienceDirect Freedom Collection</source><creator>Wang, Meng ; Rakesh, K.P. ; Leng, Jing ; Fang, Wan-Yin ; Ravindar, L. ; Channe Gowda, D. ; Qin, Hua-Li</creator><creatorcontrib>Wang, Meng ; Rakesh, K.P. ; Leng, Jing ; Fang, Wan-Yin ; Ravindar, L. ; Channe Gowda, D. ; Qin, Hua-Li</creatorcontrib><description>[Display omitted]
Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties. Synthetic amino acid/peptides based heterocyclic conjugates constitute a promising choice for the development of new, less toxic and safer conventional pharmaceutical drugs in the near future. In this review, we discuss and highlight the recent findings of the structural features that encourage biological applications of amino acid/peptides based conjugates.</description><identifier>ISSN: 0045-2068</identifier><identifier>EISSN: 1090-2120</identifier><identifier>DOI: 10.1016/j.bioorg.2017.11.007</identifier><identifier>PMID: 29169078</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino acids ; Amino Acids - chemistry ; Amino Acids - pharmacology ; Animals ; Anti-Infective Agents - chemistry ; Antineoplastic Agents - chemistry ; Biological activities ; Conjugation ; Heterocycles ; Humans ; Peptides ; Peptides - chemistry ; Peptides - pharmacology ; SAR</subject><ispartof>Bioorganic chemistry, 2018-02, Vol.76, p.113-129</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-c6388b3daea44116225e14ca07c5da223617a1c9446800bb827b35668d99001b3</citedby><cites>FETCH-LOGICAL-c362t-c6388b3daea44116225e14ca07c5da223617a1c9446800bb827b35668d99001b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29169078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Meng</creatorcontrib><creatorcontrib>Rakesh, K.P.</creatorcontrib><creatorcontrib>Leng, Jing</creatorcontrib><creatorcontrib>Fang, Wan-Yin</creatorcontrib><creatorcontrib>Ravindar, L.</creatorcontrib><creatorcontrib>Channe Gowda, D.</creatorcontrib><creatorcontrib>Qin, Hua-Li</creatorcontrib><title>Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents</title><title>Bioorganic chemistry</title><addtitle>Bioorg Chem</addtitle><description>[Display omitted]
Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties. Synthetic amino acid/peptides based heterocyclic conjugates constitute a promising choice for the development of new, less toxic and safer conventional pharmaceutical drugs in the near future. In this review, we discuss and highlight the recent findings of the structural features that encourage biological applications of amino acid/peptides based conjugates.</description><subject>Amino acids</subject><subject>Amino Acids - chemistry</subject><subject>Amino Acids - pharmacology</subject><subject>Animals</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Biological activities</subject><subject>Conjugation</subject><subject>Heterocycles</subject><subject>Humans</subject><subject>Peptides</subject><subject>Peptides - chemistry</subject><subject>Peptides - pharmacology</subject><subject>SAR</subject><issn>0045-2068</issn><issn>1090-2120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEFv1DAQhS0EotuFf4CQj1ySzjiOk3BAWlW0IFXi0p4tx57dekniYDuV-u_JaluOnGZG8948zcfYJ4QSAdXVsex9CPFQCsCmRCwBmjdsg9BBIVDAW7YBkHUhQLUX7DKlIwCibNR7diE6VB007Yb93o1-CtxY79LVTHP2jhK3YTouB5PJ8UfKFIN9tgOlr3zHcwgD34fI8yPxSJamzB090RDm8dSHPZ_COp720cy0ZG-5Oayr9IG925sh0ceXumUPN9_vr38Ud79uf17v7gpbKZELq6q27StnyEiJqISoCaU10NjaGSEqhY1B20mpWoC-b0XTV7VSreu69cW-2rIv57tzDH8WSlmPPlkaBjNRWJLGTrVS1rCe2jJ5ltoYUoq013P0o4nPGkGfMOujPmPWJ8waUa-YV9vnl4SlH8n9M71yXQXfzgJa_3zyFHWyniZLzq_MsnbB_z_hL-gSkJo</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Wang, Meng</creator><creator>Rakesh, K.P.</creator><creator>Leng, Jing</creator><creator>Fang, Wan-Yin</creator><creator>Ravindar, L.</creator><creator>Channe Gowda, D.</creator><creator>Qin, Hua-Li</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201802</creationdate><title>Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents</title><author>Wang, Meng ; Rakesh, K.P. ; Leng, Jing ; Fang, Wan-Yin ; Ravindar, L. ; Channe Gowda, D. ; Qin, Hua-Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-c6388b3daea44116225e14ca07c5da223617a1c9446800bb827b35668d99001b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amino acids</topic><topic>Amino Acids - chemistry</topic><topic>Amino Acids - pharmacology</topic><topic>Animals</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Biological activities</topic><topic>Conjugation</topic><topic>Heterocycles</topic><topic>Humans</topic><topic>Peptides</topic><topic>Peptides - chemistry</topic><topic>Peptides - pharmacology</topic><topic>SAR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Meng</creatorcontrib><creatorcontrib>Rakesh, K.P.</creatorcontrib><creatorcontrib>Leng, Jing</creatorcontrib><creatorcontrib>Fang, Wan-Yin</creatorcontrib><creatorcontrib>Ravindar, L.</creatorcontrib><creatorcontrib>Channe Gowda, D.</creatorcontrib><creatorcontrib>Qin, Hua-Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Meng</au><au>Rakesh, K.P.</au><au>Leng, Jing</au><au>Fang, Wan-Yin</au><au>Ravindar, L.</au><au>Channe Gowda, D.</au><au>Qin, Hua-Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents</atitle><jtitle>Bioorganic chemistry</jtitle><addtitle>Bioorg Chem</addtitle><date>2018-02</date><risdate>2018</risdate><volume>76</volume><spage>113</spage><epage>129</epage><pages>113-129</pages><issn>0045-2068</issn><eissn>1090-2120</eissn><abstract>[Display omitted]
Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties. Synthetic amino acid/peptides based heterocyclic conjugates constitute a promising choice for the development of new, less toxic and safer conventional pharmaceutical drugs in the near future. In this review, we discuss and highlight the recent findings of the structural features that encourage biological applications of amino acid/peptides based conjugates.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29169078</pmid><doi>10.1016/j.bioorg.2017.11.007</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0045-2068 |
| ispartof | Bioorganic chemistry, 2018-02, Vol.76, p.113-129 |
| issn | 0045-2068 1090-2120 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1968445022 |
| source | ScienceDirect Freedom Collection |
| subjects | Amino acids Amino Acids - chemistry Amino Acids - pharmacology Animals Anti-Infective Agents - chemistry Antineoplastic Agents - chemistry Biological activities Conjugation Heterocycles Humans Peptides Peptides - chemistry Peptides - pharmacology SAR |
| title | Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T04%3A15%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Amino%20acids/peptides%20conjugated%20heterocycles:%20A%20tool%20for%20the%20recent%20development%20of%20novel%20therapeutic%20agents&rft.jtitle=Bioorganic%20chemistry&rft.au=Wang,%20Meng&rft.date=2018-02&rft.volume=76&rft.spage=113&rft.epage=129&rft.pages=113-129&rft.issn=0045-2068&rft.eissn=1090-2120&rft_id=info:doi/10.1016/j.bioorg.2017.11.007&rft_dat=%3Cproquest_cross%3E1968445022%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c362t-c6388b3daea44116225e14ca07c5da223617a1c9446800bb827b35668d99001b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1968445022&rft_id=info:pmid/29169078&rfr_iscdi=true |