Serum paraoxonase‐1 activity is inversely related to free thyroxine in euthyroid subjects: The PREVEND Cohort Study

• Published in: European journal of clinical investigation 2018-01, Vol.48 (1), p.n/a
• Main Authors: van Tienhoven‐Wind, Lynnda J. N., Gruppen, Eke G., James, Richard W., Bakker, Stephan J. L., Gans, Rijk O. B., Dullaart, Robin P. F.
• Format: Article
• Language: English
• Subjects: Age; Apolipoproteins; Arteriosclerosis; Arylesterase; Atherosclerosis; Cardiovascular diseases; Cholesterol; Cohort analysis; free thyroxine; High density lipoprotein; high‐density lipoproteins; Laboratory tests; Lipids; Metabolic syndrome; Oxidative stress; Paraoxonase; paraoxonase‐1; Thyroid; thyroid function; Thyroid gland; Thyroid-stimulating hormone; Thyroxine; Triglycerides; Triiodothyronine
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1111/eci.12860

Background Low‐normal thyroid function within the euthyroid range has been suggested to enhance atherosclerosis susceptibility. Paraoxonase‐1 (PON‐1) may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of PON‐1 with thyroid stimulating hormone (TSH), free T4, free T3, lipids and apolipoprotein (apo)A‐I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS). Materials and methods Serum PON‐1 activity (arylesterase activity), TSH, free T4, free T3, lipids and apoA‐I was measured in 2206 euthyroid subjects (aged 28‐75 years; 1138 men (age 49 ± 13 years) and 1068 women (age 46 ± 12 years), recruited from the general population (PREVEND cohort). Results In age‐ and sex‐adjusted analysis, PON‐1 activity (divided into tertiles) was positively related to TSH (β = −0.045, P = .036) and inversely to free T4 (β = −0.042, P = .050) but not to free T3 (β = −0.027, P = .20). PON‐1 activity was positively related to total cholesterol, non‐HDL cholesterol and triglycerides, as well as to HDL cholesterol and apoA‐I (P