Comparative 2H-labelled α-tocopherol biokinetics in plasma, lipoproteins, erythrocytes, platelets and lymphocytes in normolipidaemic males

The biokinetics of newly absorbed vitamin E in blood components was investigated in normolipidaemic males. Subjects (n 12) ingested encapsulated 150 mg 2H-labelled RRR-α-tocopheryl acetate with a standard meal. Blood was collected at 3, 6, 9, 12, 24 and 48 h post-ingestion. 2H-Labelled and pre-exist...

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Bibliographic Details
Published in:British journal of nutrition 2005-07, Vol.94 (1), p.92-99
Main Authors: Jeanes, Yvonne M., Hall, Wendy L., Lodge, John K.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Deuterated
Enzymes. Coenzymes. Vitamins. Pigments
Erythrocytes
Fundamental and applied biological sciences. Psychology
Lymphocytes
Metabolisms and neurohumoral controls
Plasma
Platelets
Tocopherol
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The biokinetics of newly absorbed vitamin E in blood components was investigated in normolipidaemic males. Subjects (n 12) ingested encapsulated 150 mg 2H-labelled RRR-α-tocopheryl acetate with a standard meal. Blood was collected at 3, 6, 9, 12, 24 and 48 h post-ingestion. 2H-Labelled and pre-existing unlabelled α-tocopherol (α-T) was determined in plasma, lipoproteins, erythrocytes, platelets and lymphocytes by LC–MS. In all blood components, labelled α-T concentration significantly increased while unlabelled decreased following ingestion (P
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN20051434