Cardiac Biomarker Release after Endurance Exercise in Male and Female Adults and Adolescents

• Published in: The Journal of pediatrics 2017-12, Vol.191, p.96-102
• Main Authors: Legaz-Arrese, Alejandro, Carranza-García, Luis E., Navarro-Orocio, Ricardo, Valadez-Lira, Alberto, Mayolas-Pi, Carmen, Munguía-Izquierdo, Diego, Reverter-Masía, Joaquín, George, Keith
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Biomarkers - blood; Child; Cross-Sectional Studies; Female; high-sensitivity cardiac troponin T; Humans; Male; Middle Aged; Natriuretic Peptide, Brain - blood; NH2-terminal pro-brain natriuretic peptide; Peptide Fragments - blood; Physical Endurance - physiology; sex; Sex Factors; swimming; Swimming - physiology; Tanner stage; Troponin T - blood
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2017.08.061

To compare the responses of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal probrain natriuretic peptide (NT-proBNP) after 60 minutes of swimming in male and female adults and adolescents with different pubertal status. Adolescent swimmers (25 male and 25 female) and adult swimmers (7 male and 9 female) participated in a 60-minute maximal swimming test with serial assessment of hs-cTnT and NT-proBNP at rest, immediately postexercise, and at 1, 3, 6, 12, and 24 hours postexercise. Adolescents were classified according to pubertal status: Tanner stages 3 (n = 14), 4 (n = 22), and 5 (n = 14). Exercise resulted in an increase in both biomarkers. hs-cTnT responses to exercise were similar in adolescents with different pubertal status and adults, although there was substantial individual variability in peak hs-cTnT, with the upper reference limit exceeding in 62% of the participants. Postexercise kinetics for hs-cTnT were largely consistent across all groups with a return to near baseline levels 24 hours postexercise. The male participants showed higher values of hs-cTnT at baseline and postexercise. All groups had similar NT-proBNP responses to acute exercise and recovery. One swimmer exceeded the upper reference limit for NT-proBNP. An exercise-associated increase in hs-cTnT and NT-proBNP occurred in response to a 60-minute maximal swimming test that was independent of pubertal status/adolescent vs adults. The present data also suggests that baseline and postexercise hs-cTnT values are higher in male compared with female, with no sex differences in NT-proBNP values.