Lateral habenula in the pathophysiology of depression

Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort without a clear cause. Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Re...

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Bibliographic Details
Published in:Current opinion in neurobiology 2018-02, Vol.48, p.90-96
Main Authors: Yang, Yan, Wang, Hao, Hu, Ji, Hu, Hailan
Format: Article
Language:English
Subjects:
Animals
Depressive Disorder - pathology
Disease Models, Animal
Habenula - pathology
Habenula - physiopathology
Humans
Nerve Net - pathology
Neurons - physiology
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Summary:Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort without a clear cause. Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of depression. Increasing evidence from rodent, non-human primate and human studies indicates that the aberrant activity of the LHb is associated with depressive symptoms such as helplessness, anhedonia, and excessive negative focus. Revealing the molecular, cellular and circuit properties of the LHb will help explain how abnormalities in LHb activity are linked to depressive disorders, and shed light on developing novel strategies for depression treatment.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2017.10.024