Isosteric ribavirin analogues: Synthesis and antiviral activities

[Display omitted] The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the propo...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2018-01, Vol.28 (1), p.11-14
Main Authors: Zhurilo, Nikolay I., Chudinov, Mikhail V., Matveev, Andrey V., Smirnova, Olga S., Konstantinova, Irina D., Miroshnikov, Anatoly I., Prutkov, Alexander N., Grebenkina, Lyubov E., Pulkova, Natalya V., Shvets, Vitaly I.
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antivirals
Cell Survival - drug effects
Cercopithecus aethiops
Hepacivirus - drug effects
Herpesvirus 1, Human - drug effects
Humans
Influenza A virus - drug effects
Isosterism
Nucleoside analogues
Ribavirin
Ribavirin - analogs & derivatives
Ribavirin - chemical synthesis
Ribavirin - pharmacology
Vero Cells
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Summary:[Display omitted] The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2017.11.029