Ultrastructure of Rat Kidneys after Intravenous Administration of Modified Magnetite Nanoparticles

The ultrastructure of nephrocytes of the proximal and distal convoluted tubules, podocytes, mesangial cells, and macrophages of the interstitial connective tissue was studied after single intravenous administration of magnetite nanoparticles modified with chitosan (magnetic nanospheres) or lipids (m...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-12, Vol.164 (2), p.218-222
Main Authors: Mil’to, I. V., Sukhodolo, I. V., Ivanova, V. V., Yusubov, M. S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chitosan
Distal tubules
Internal Medicine
Intravenous administration
Laboratory Medicine
Lipids
Liposomes
Macrophages
Magnetite
Mesangial cells
Nanoparticles
Pathology
Proximal tubules
Rodents
Transmission electron microscopy
Tubules
Ultrastructure
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Description
Summary:The ultrastructure of nephrocytes of the proximal and distal convoluted tubules, podocytes, mesangial cells, and macrophages of the interstitial connective tissue was studied after single intravenous administration of magnetite nanoparticles modified with chitosan (magnetic nanospheres) or lipids (magnetic liposomes). Transmission electron microscopy showed ultrastructural features of absorption of magnetite nanoparticles. The shape, size, and number of vesicles containing nanoparticles in nephrocytes of convoluted tubules and macrophages after administration of the suspensions of magnetic nanospheres and magnetic liposomes were described.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3962-0