New sensor based on membranes with magnetic nano-inclusions for early diagnosis in periodontal disease

A series of sodium selective membranes with magnetic nano-inclusions using p-tertbutyl calix[4]arene as ionophore and polymeric matrix (polyvinyl chloride) have been developed, and the corresponding sodium selective sensors were obtained for the first time. A linear range was registered between 3.1...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2018-04, Vol.102, p.336-344
Main Authors: Totu, Eugenia Eftimie, Isildak, Ibrahim, Nechifor, Aurelia Cristina, Cristache, Corina Marilena, Enachescu, Marius
Format: Article
Language:English
Subjects:
Biosensing Techniques
Early Diagnosis
Gingival Crevicular Fluid - chemistry
Humans
Ion-selective polymeric matrix
Ionophores - chemistry
Ions - isolation & purification
Magnetic nano-carriers
Membranes, Artificial
Needle sodium sensor
Periodontal Diseases - diagnosis
Periodontal pocket
Polymeric ion-selective electrodes
Polyvinyl Chloride - chemistry
Potentiometry
Sodium - chemistry
Sodium - isolation & purification
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Summary:A series of sodium selective membranes with magnetic nano-inclusions using p-tertbutyl calix[4]arene as ionophore and polymeric matrix (polyvinyl chloride) have been developed, and the corresponding sodium selective sensors were obtained for the first time. A linear range was registered between 3.1 × 10−5 and 10−1moldm−3 and near Nernstian electrochemical answer: 55.73mV/decade has been recoreded for PVC (polyvinyl chloride) – based sodium selective sensor, with a response time of 45s. Due to their small dimensions, sensors could be used for measuring ions from the gingival crevicular fluid directly into the peri-odontal pocket, avoiding the difficulties of collecting an appropriate amount of fluid for analysis. Alterations in the inorganic ions level could be evidenced with this new device, assisting the early diagnosis and prevention of periodontal disease. [Display omitted] •Selective membranes with magnetic nanoinclusions were developed and corresponding sodium selective sensors were obtained.•Electrochemical impedance analysis for lower bulk resistance was used for membranes compositions optimization.•Developed sensor could be used for early diagnosis of periodontitis by sodium level direct measurement in the GCF.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2017.11.003