Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan

We explored the effects of chondroitin sulfate on knee osteoarthritis in a one-year, randomized, double-blind, dose-comparison study. Patients with painful, Kellgren–Lawrence grade 2–3, osteoarthritis of the knee were treated with oral chondroitin sulfate at a dose of either 260 mg/d (low-dose group...

Full description

Saved in:
Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2018/02/01, Vol.41(2), pp.163-171
Main Authors: Morita, Mitsuhiro, Yamada, Kotaro, Date, Hideki, Hayakawa, Kazue, Sakurai, Hidetomo, Yamada, Harumoto
Format: Article
Language:English
Subjects:
Aged
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis
Biomarkers - blood
Cartilage diseases
Cartilage oligomeric matrix protein
Cartilage Oligomeric Matrix Protein - blood
Chondroitin sulfate
Chondroitin Sulfates - administration & dosage
Chondroitin Sulfates - adverse effects
Chondroitin Sulfates - therapeutic use
clinical trial
Clinical trials
Dose-Response Relationship, Drug
Double-Blind Method
Double-blind studies
Female
Humans
Hyaluronic acid
Hyaluronic Acid - blood
Japan
Knee
Knee Joint - diagnostic imaging
Knee Joint - drug effects
Knee Joint - immunology
Knee Joint - physiopathology
Male
Matrix protein
Middle Aged
Osteoarthritis
Osteoarthritis, Knee - blood
Osteoarthritis, Knee - diagnostic imaging
Osteoarthritis, Knee - drug therapy
Osteoarthritis, Knee - physiopathology
Pain
Pain Measurement
pain-management
Radiography
Randomization
randomized controlled trial
Severity of Illness Index
Sulfates
Tablets
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We explored the effects of chondroitin sulfate on knee osteoarthritis in a one-year, randomized, double-blind, dose-comparison study. Patients with painful, Kellgren–Lawrence grade 2–3, osteoarthritis of the knee were treated with oral chondroitin sulfate at a dose of either 260 mg/d (low-dose group, control group) or 1560 mg/d (high-dose group). Symptoms were evaluated by the Lequesne’s index and visual analog scale for pain. We made subgroup analyses according to background symptom severity (Lequesne’s index ≥8 or
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b17-00556