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Drug-related neuropathies: analysis of the French Adverse Drug Reaction Database 1995-2005
Drug-induced neuropathies are mainly sensory and subacute. The pathophysiological mechanisms associated with them are not clearly established and few pharmacoepidemiologic studies are available. This study investigated spontaneous reports of peripheral neuropathies reported to the French Adverse Dru...
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| Published in: | La Presse médicale (1983) 2008-06, Vol.37 (6 Pt 1), p.935-942 |
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| container_end_page | 942 |
| container_issue | 6 Pt 1 |
| container_start_page | 935 |
| container_title | La Presse médicale (1983) |
| container_volume | 37 |
| creator | Durrieu, Geneviève Lacroix, Isabelle Olivier, Pascale Sommet, Agnès Sénard, Jean-Michel Montastruc, Jean-Louis |
| description | Drug-induced neuropathies are mainly sensory and subacute. The pathophysiological mechanisms associated with them are not clearly established and few pharmacoepidemiologic studies are available.
This study investigated spontaneous reports of peripheral neuropathies reported to the French Adverse Drug Reaction (pharmacovigilance) database over a ten-year period.
Between January 1995 and April 2005, 1110 cases were reported, predominantly among men (60%). Patients' mean age was 53.6 years. Most of these reports concerned sensory neuropathies, and 538 (48%) cases were considered "serious". Neuropathies related to dermatologic drugs (mainly retinoids) were serious in 85.7% of cases. Reactions were tentatively attributed to the following pharmacological classes, in decreasing order: antiviral and antibacterial (43.6%), antineoplastic and immunosuppressant (15.9%), cardiovascular (15.9%), central nervous system (7.9%) and gastrointestinal and metabolism (4.8%) agents. Specific drugs suspected of causing neuropathies were stavudine (198 cases), didanosine (134), lamivudine (124), thalidomide (57), ritonavir (55), zalcitabine (53) and amiodarone (47). This study allowed us to consider whether 2 other drugs (allopurinol and flecainide acetate) might be related to the occurrence of neuropathies.
This work points out the usefulness of spontaneous reports of adverse drug reactions to regional adverse drug reaction reporting centers to help determine the relative frequency of suspected reactions to different drugs and to help detect drugs not previously known to induce these reactions. |
| doi_str_mv | 10.1016/j.lpm.2007.08.020 |
| format | article |
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This study investigated spontaneous reports of peripheral neuropathies reported to the French Adverse Drug Reaction (pharmacovigilance) database over a ten-year period.
Between January 1995 and April 2005, 1110 cases were reported, predominantly among men (60%). Patients' mean age was 53.6 years. Most of these reports concerned sensory neuropathies, and 538 (48%) cases were considered "serious". Neuropathies related to dermatologic drugs (mainly retinoids) were serious in 85.7% of cases. Reactions were tentatively attributed to the following pharmacological classes, in decreasing order: antiviral and antibacterial (43.6%), antineoplastic and immunosuppressant (15.9%), cardiovascular (15.9%), central nervous system (7.9%) and gastrointestinal and metabolism (4.8%) agents. Specific drugs suspected of causing neuropathies were stavudine (198 cases), didanosine (134), lamivudine (124), thalidomide (57), ritonavir (55), zalcitabine (53) and amiodarone (47). This study allowed us to consider whether 2 other drugs (allopurinol and flecainide acetate) might be related to the occurrence of neuropathies.
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This study investigated spontaneous reports of peripheral neuropathies reported to the French Adverse Drug Reaction (pharmacovigilance) database over a ten-year period.
Between January 1995 and April 2005, 1110 cases were reported, predominantly among men (60%). Patients' mean age was 53.6 years. Most of these reports concerned sensory neuropathies, and 538 (48%) cases were considered "serious". Neuropathies related to dermatologic drugs (mainly retinoids) were serious in 85.7% of cases. Reactions were tentatively attributed to the following pharmacological classes, in decreasing order: antiviral and antibacterial (43.6%), antineoplastic and immunosuppressant (15.9%), cardiovascular (15.9%), central nervous system (7.9%) and gastrointestinal and metabolism (4.8%) agents. Specific drugs suspected of causing neuropathies were stavudine (198 cases), didanosine (134), lamivudine (124), thalidomide (57), ritonavir (55), zalcitabine (53) and amiodarone (47). This study allowed us to consider whether 2 other drugs (allopurinol and flecainide acetate) might be related to the occurrence of neuropathies.
This work points out the usefulness of spontaneous reports of adverse drug reactions to regional adverse drug reaction reporting centers to help determine the relative frequency of suspected reactions to different drugs and to help detect drugs not previously known to induce these reactions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adverse Drug Reaction Reporting Systems</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>France</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurotoxicity Syndromes - epidemiology</subject><issn>0755-4982</issn><issn>2213-0276</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNo1kE1LxDAYhIMobl39AV4kJ2-tyds0Tbwtu64KC4LoxUtJmrdul36ZtML-e1dcTwPDM8MwhFxzlnDG5d0uaYY2AcbyhKmEATshEQBPYwa5PCURy7MsFlrBjFyEsGMMuMj1OZlxBQK0UBH5WPnpM_bYmBEd7XDy_WDGbY3hnprONPtQB9pXdNwiXXvsyi1duG_0Aelvkr6iKce67-jKjMaag821zuLDpuySnFWmCXh11Dl5Xz-8LZ_izcvj83KxiQeeszF2Diw6Lq3gleXGYqYYLwFAVlaglHkGmQJITcUNGrQitQqtq0SpUulKkc7J7V_v4PuvCcNYtHUosWlMh_0UCq6l1kKnB_DmCE62RVcMvm6N3xf_b6Q_m2BhzA</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Durrieu, Geneviève</creator><creator>Lacroix, Isabelle</creator><creator>Olivier, Pascale</creator><creator>Sommet, Agnès</creator><creator>Sénard, Jean-Michel</creator><creator>Montastruc, Jean-Louis</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7TK</scope><scope>7U2</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20080601</creationdate><title>Drug-related neuropathies: analysis of the French Adverse Drug Reaction Database 1995-2005</title><author>Durrieu, Geneviève ; Lacroix, Isabelle ; Olivier, Pascale ; Sommet, Agnès ; Sénard, Jean-Michel ; Montastruc, Jean-Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p170t-dd2bed16b41fb1abe5801c2226fb4e6675258223af1aeaeb43b8ebdf4c836dc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adverse Drug Reaction Reporting Systems</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>France</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurotoxicity Syndromes - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durrieu, Geneviève</creatorcontrib><creatorcontrib>Lacroix, Isabelle</creatorcontrib><creatorcontrib>Olivier, Pascale</creatorcontrib><creatorcontrib>Sommet, Agnès</creatorcontrib><creatorcontrib>Sénard, Jean-Michel</creatorcontrib><creatorcontrib>Montastruc, Jean-Louis</creatorcontrib><creatorcontrib>Réseau français des centres régionaux de pharmacovigilance (CRPVs)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>La Presse médicale (1983)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durrieu, Geneviève</au><au>Lacroix, Isabelle</au><au>Olivier, Pascale</au><au>Sommet, Agnès</au><au>Sénard, Jean-Michel</au><au>Montastruc, Jean-Louis</au><aucorp>Réseau français des centres régionaux de pharmacovigilance (CRPVs)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug-related neuropathies: analysis of the French Adverse Drug Reaction Database 1995-2005</atitle><jtitle>La Presse médicale (1983)</jtitle><addtitle>Presse Med</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>37</volume><issue>6 Pt 1</issue><spage>935</spage><epage>942</epage><pages>935-942</pages><issn>0755-4982</issn><eissn>2213-0276</eissn><abstract>Drug-induced neuropathies are mainly sensory and subacute. The pathophysiological mechanisms associated with them are not clearly established and few pharmacoepidemiologic studies are available.
This study investigated spontaneous reports of peripheral neuropathies reported to the French Adverse Drug Reaction (pharmacovigilance) database over a ten-year period.
Between January 1995 and April 2005, 1110 cases were reported, predominantly among men (60%). Patients' mean age was 53.6 years. Most of these reports concerned sensory neuropathies, and 538 (48%) cases were considered "serious". Neuropathies related to dermatologic drugs (mainly retinoids) were serious in 85.7% of cases. Reactions were tentatively attributed to the following pharmacological classes, in decreasing order: antiviral and antibacterial (43.6%), antineoplastic and immunosuppressant (15.9%), cardiovascular (15.9%), central nervous system (7.9%) and gastrointestinal and metabolism (4.8%) agents. Specific drugs suspected of causing neuropathies were stavudine (198 cases), didanosine (134), lamivudine (124), thalidomide (57), ritonavir (55), zalcitabine (53) and amiodarone (47). This study allowed us to consider whether 2 other drugs (allopurinol and flecainide acetate) might be related to the occurrence of neuropathies.
This work points out the usefulness of spontaneous reports of adverse drug reactions to regional adverse drug reaction reporting centers to help determine the relative frequency of suspected reactions to different drugs and to help detect drugs not previously known to induce these reactions.</abstract><cop>France</cop><pmid>18242948</pmid><doi>10.1016/j.lpm.2007.08.020</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0755-4982 |
| ispartof | La Presse médicale (1983), 2008-06, Vol.37 (6 Pt 1), p.935-942 |
| issn | 0755-4982 2213-0276 |
| language | fre |
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| source | Elsevier |
| subjects | Adolescent Adult Adverse Drug Reaction Reporting Systems Aged Aged, 80 and over Child Child, Preschool Databases, Factual Female France Humans Infant Male Middle Aged Neurotoxicity Syndromes - epidemiology |
| title | Drug-related neuropathies: analysis of the French Adverse Drug Reaction Database 1995-2005 |
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