Expression patterns of duplicated snail genes in the leech Helobdella

snail gene family members are zinc-finger transcription factors with key roles in morphogenesis. Involvement of snail family genes in mesoderm formation has been observed in insects and mammals. The snail genes are also involved in cell motility, neural differentiation, cell fate, survival decision,...

Full description

Saved in:
Bibliographic Details
Published in:Development genes and evolution 2017-11, Vol.227 (6), p.415-421
Main Authors: Kim, Jin-Se, Kwak, Hee-Jin, Medina Jiménez, Brenda Irene, Park, Soon Cheol, Xiao, Ping, Weisblat, David A., Cho, Sung-Jin
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Cell Biology
Cell fate
Cell survival
Cloning, Molecular
Developmental Biology
Evolutionary Biology
Gene Duplication
Helobdella
Leeches - genetics
Leeches - growth & development
Leeches - metabolism
Life Sciences
Mesoderm
Morphogenesis
Phylogeny
Plant Genetics and Genomics
Polymerase chain reaction
Proboscis
Sequence Analysis, DNA
Short Communication
Snail Family Transcription Factors - chemistry
Snail Family Transcription Factors - genetics
Snail Family Transcription Factors - metabolism
Snail protein
Transcription factors
Transcriptome
Ventral nerve cord
Zinc finger proteins
Zoology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:snail gene family members are zinc-finger transcription factors with key roles in morphogenesis. Involvement of snail family genes in mesoderm formation has been observed in insects and mammals. The snail genes are also involved in cell motility, neural differentiation, cell fate, survival decision, and left-right identity. The functions of snail genes have been studied primarily among ecdysozoans and deuterostomes, with relatively little work carried out in lophotrochozoans. In this study, we isolated two snail homologs ( Hau-snail1 and Hau-snail2 ) from the leech Helobdella austinensis . We characterized the temporal and spatial expression patterns of these two genes by semi-quantitative RT-PCR and in situ hybridization. The expression of Hau-snail 1 and Hau-snail 2 correlates with ventral nerve cord (VNC) development, segmental mesoderm, and with a ring of cells that comes to lie at the base of the leech proboscis, respectively, showing similarity to the divergent expression of duplicated snail genes in polychaetes. Our results do not support the function of lophotrochozoan snail genes in mesoderm specification.
ISSN:0949-944X
1432-041X
DOI:10.1007/s00427-017-0598-z