Cover Picture: CXCL12‐induced partitioning of flotillin‐1 with lipid rafts plays a role in CXCR4 function – Eur. J. Immunol. 8/2007

Giri et al. (pp. 2104–2116) determine that flotillin‐1, but not flotillin‐2, is specifically recruited to lipid rafts following CXCL12 stimulation of human T cells. The cover image taken from this article shows a Jurkat cell transfected with control siRNA and stimulated with CXCL12; the location of...

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Bibliographic Details
Published in:European Journal of Immunology 2007-08, Vol.37 (8), p.n/a
Main Authors: Giri, Banabihari, Dixit, Vishwa D., Ghosh, Manik C., Collins, Gary D., Khan, Islam U., Madara, Karen, Weeraratna, Ashani T., Taub, Dennis D.
Format: Article
Language:English
Subjects:
Chemotaxis
CXCL12
CXCR4
Flotillin‐1
Lipid rafts
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Summary:Giri et al. (pp. 2104–2116) determine that flotillin‐1, but not flotillin‐2, is specifically recruited to lipid rafts following CXCL12 stimulation of human T cells. The cover image taken from this article shows a Jurkat cell transfected with control siRNA and stimulated with CXCL12; the location of flotillin‐1 (red), CXCR4 (green) and the nucleus (blue) are determined by immunofluorescence. A distinct “capped” phenotype is observed with significant recruitment and colocalization (yellow/orange) of flotillin‐1 and CXCR4 in lipid rafts; such CXCR4 recruitment is decreased in flotillin‐1 siRNA transfected cells. Together the data of Giri et al. indicate a role for flotillin‐1 in chemokine receptor signalling.
ISSN:0014-2980
1521-4141
1365-2567
DOI:10.1002/eji.200790032