Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension

Chlorogenic acid, a polyphenol found in coffee, has antihypertensive actions, but epidemiologic data on the effects of coffee on blood pressure are controversial. Specific coffee components that inhibit the hypotensive effect of chlorogenic acid and the physiologic mechanisms underlying the effects...

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Bibliographic Details
Published in:FEBS letters 2006-04, Vol.580 (9), p.2317-2322
Main Authors: Suzuki, Atsushi, Fujii, Akihiko, Yamamoto, Naoki, Yamamoto, Masaki, Ohminami, Hideo, Kameyama, Akiyo, Shibuya, Yusuke, Nishizawa, Yoshinori, Tokimitsu, Ichiro, Saito, Ikuo
Format: Article
Language:English
Subjects:
Animals
Aorta - enzymology
Blood pressure
Chlorogenic acid
Chlorogenic Acid - administration & dosage
Chlorogenic Acid - chemistry
Coffee - adverse effects
Coffee - chemistry
DCC
droplet countercurrent chromatography
Endothelium, Vascular - enzymology
GCE
Gene Expression Regulation, Enzymologic - drug effects
green coffee bean extract
HHQ
high performance liquid chromatography
HPLC
Hydroquinones - adverse effects
Hydroquinones - chemistry
hydroxyhydroquinone
Hypertension - metabolism
L-NAME
Male
Models, Genetic
N G-nitro-l-arginine methyl ester
NADPH Oxidases - biosynthesis
Nitric oxide
Nitric Oxide - metabolism
Rats
Rats, Inbred SHR
reactive oxygen species
ROS
SHR
Spontaneously hypertensive rat
Vasodilation
Vasodilation - drug effects
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Summary:Chlorogenic acid, a polyphenol found in coffee, has antihypertensive actions, but epidemiologic data on the effects of coffee on blood pressure are controversial. Specific coffee components that inhibit the hypotensive effect of chlorogenic acid and the physiologic mechanisms underlying the effects of coffee without these components were investigated. One component, hydroxyhydroquinone (HHQ), inhibited the hypotensive effects of chlorogenic acid in spontaneously hypertensive rats (SHR). The attenuation of hypertension by HHQ-free coffee was associated with nitric oxide, the suppression of mRNA expression of NAD(P)H oxidase, and the improvement in endothelium-dependent vasodilation in the aorta. Thus, HHQ-free coffee might regulate vascular tone by improving the bioavailability of nitric oxide in SHR.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2006.03.047