Reduced incidence of insect-bite hypersensitivity in Icelandic horses is associated with a down-regulation of interleukin-4 by interleukin-10 and transforming growth factor- beta 1

Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by IgE-mediated reactions to bites of insects of the genus Culicoides. IBH does not occur in Iceland due to the absence of Culicoides. However, Icelandic horses exported to mainland Europe as adults (1st generation) have a...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 2008-03, Vol.122 (1-2), p.65-75
Main Authors: Hamza, E, Wagner, B, Jungi, T W, Mirkovitch, J, Marti, E
Format: Article
Language:English
Subjects:
Culicoides
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Summary:Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by IgE-mediated reactions to bites of insects of the genus Culicoides. IBH does not occur in Iceland due to the absence of Culicoides. However, Icelandic horses exported to mainland Europe as adults (1st generation) have a >=50% incidence of developing IBH. In contrast, their progeny (2nd generation) has a
ISSN:0165-2427
DOI:10.1016/j.vetimm.2007.10.018