Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy

This is the first report of a neonatal withdrawal syndrome associated with maternal hydroxyzine treatment (150 mg/day) confirmed by measurements of hydroxyzine plasma concentrations in the mother and infant after birth. Hydroxyzine plasma concentrations were measured by liquid chromatography–mass sp...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2005-11, Vol.20 (4), p.573-574
Main Authors: Serreau, Raphaël, Komiha, Meriem, Blanc, Florence, Guillot, François, Jacqz-Aigrain, Evelyne
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Dosage
Embryology: invertebrates and vertebrates. Teratology
Female
Fetal Blood - chemistry
Fundamental and applied biological sciences. Psychology
Histamine H1 Antagonists - administration & dosage
Histamine H1 Antagonists - adverse effects
Histamine H1 Antagonists - blood
HPLC mass spectrometry
Humans
Hydroxyzine
Hydroxyzine - administration & dosage
Hydroxyzine - adverse effects
Hydroxyzine - blood
Infant, Newborn
Infant, Newborn, Diseases - chemically induced
Male
Maternal-Fetal Exchange
Medical sciences
Neonate
Pregnancy
Seizure
Seizures - chemically induced
Substance Withdrawal Syndrome - etiology
Teratology. Teratogens
Toxicity
Toxicology
Withdrawal syndrome
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Summary:This is the first report of a neonatal withdrawal syndrome associated with maternal hydroxyzine treatment (150 mg/day) confirmed by measurements of hydroxyzine plasma concentrations in the mother and infant after birth. Hydroxyzine plasma concentrations were measured by liquid chromatography–mass spectrometry. Neurological symptoms with low neonatal concentrations of hydroxyzine may be due to a withdrawal syndrome. According to previous observations and this case report, clinicians should be warned of this possible rare neurological complication of hydroxyzine in neonates born from long term treated mothers.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2005.03.005