Multiple focal nodular hyperplasia: MRI features

• Published in: Clinical imaging 2018-05, Vol.49, p.89-96
• Main Authors: Busireddy, Kiran K., Ramalho, Miguel, AlObaidy, Mamdoh, Matos, António P., Burke, Lauren M., Dale, Brian M., Semelka, Richard C.
• Format: Article
• Language: English
• Subjects: Abdomen; Adolescent; Adult; Aged; Confidence intervals; Contrast agents; Contrast Media; FDA approval; Female; Females; FNH; Focal Nodular Hyperplasia - diagnostic imaging; Gangrene; Hepatobiliary contrast agents; Humans; Hyperplasia; Lesions; Liver; Liver - diagnostic imaging; Magnetic Resonance Imaging; Male; Middle Aged; MRI; Multiple nodular focal hyperplasias; NMR; Nuclear magnetic resonance; Portal Vein - diagnostic imaging; Retrospective Studies; Studies; Telangiectatic; Tumors; Young Adult
• ISSN: 0899-7071; 1873-4499
• DOI: 10.1016/j.clinimag.2017.11.010

To describe MRI features of multiple Focal Nodular Hyperplasia (FNHs). 40 consecutive subjects (37 females, mean age, 38.8years) were included. All studies were independently reviewed. This was an observational study to define the radiological features of multifocal FNH. 130 lesions were evaluated. The majority (88.5%), were peripheral in location. 92.3% lesions were lobulated. Marked enhancement was present in 94.6% lesions. In the portal venous and delayed phase, 46.2% and 47.7% lesions were mildly hyperintense. Central scar was present in 77% lesions. Distinctive features included predominant subcapsular location and mild hyperintensity in the delayed phase, seen in nearly 50% of FNHs. •This is the first series description of multiple FNHs by MRI.•The appearance of FNHs in the setting of multiple FNHs is comparable to that of solitary FNHs.•The majority of lesions were subcapsular in location.•Mild hyperintensity was seen in the interstitial phase in near 50% of the lesions.•Fatty FNHs were not uncommon and were seen in 11.5% of lesions.