pH sensitive surfactant-stabilized Fe3O4 magnetic nanocarriers for dual drug delivery

[Display omitted] •Novel pH sensitive surfactant-stabilized Fe3O4 nanocarriers were developed.•Nanocarriers are water-dispersible, non-toxic and protein resistant in nature.•Capable of simultaneous loading of hydrophilic and hydrophobic anticancer agents.•Possess potential therapeutic efficacy upon...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2018-02, Vol.162, p.163-171
Main Authors: Dutta, Bijaideep, Shetake, Neena G., Barick, B.K., Barick, K.C., Pandey, B.N., Priyadarsini, K.I., Hassan, P.A.
Format: Article
Language:English
Subjects:
Curcumin
Doxorubicin
Drug delivery
Fe3O4
Hyperthermia
Magnetic
Nanoparticles
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Summary:[Display omitted] •Novel pH sensitive surfactant-stabilized Fe3O4 nanocarriers were developed.•Nanocarriers are water-dispersible, non-toxic and protein resistant in nature.•Capable of simultaneous loading of hydrophilic and hydrophobic anticancer agents.•Possess potential therapeutic efficacy upon conjugated with anticancer drugs.•Nanocarriers also show excellent heating efficacy under AC magnetic field. Highly water-dispersible surfactant-stabilized Fe3O4 magnetic nanocarriers (SMNCs) were prepared by self-assembly of anionic surfactant, sodium dodecyl sulphate (SDS) on hydrophobic (oleic acid coated) nanoparticles and their biomedical applications were investigated. These nanocarriers have an average size of about 10nm and possess tunable surface charge properties. The formation of an organic coating of SDS was evident from infrared spectroscopy, dynamic light scattering, zeta-potential and thermogravimetric measurements. These nanocarriers were used for loading of both hydrophilic and hydrophobic anticancer agents such as doxorubicin hydrochloride (DOX) and curcumin (CUR), respectively. DOX was conjugated onto the surface of nanocarriers through electrostatic interaction, whereas CUR was encapsulated into the hydrophobic interlayer between oleic acid and SDS. The toxicity and cellular internalization of drug loaded nanocarriers were investigated against WEHI-164 cancer cell line. Specifically, the drug loading, pH sensitive drug release and cellular internalization studies suggested that these nanocarriers are suitable for dual drug delivery. Furthermore, they show good heating ability under AC magnetic field, thus can be used as effective heating source for hyperthermia treatment of cancer.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2017.11.054