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Intravenous immunoglobulin–induced acute thrombocytopenia
BACKGROUND Intravenous immunoglobulin (IVIG) has known efficacy in various hematologic conditions, including immune thrombocytopenic purpura. STUDY DESIGN AND METHODS We present the clinical course of a patient with splenic marginal zone lymphoma, who developed acute thrombocytopenia on three consec...
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| Published in: | Transfusion (Philadelphia, Pa.) Pa.), 2018-02, Vol.58 (2), p.493-497 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4199-4616c5e04c5e07e29d58bf36f7ff526bf5c75c164790295fb26d889f4d0c34f43 |
| container_end_page | 497 |
| container_issue | 2 |
| container_start_page | 493 |
| container_title | Transfusion (Philadelphia, Pa.) |
| container_volume | 58 |
| creator | Gurevich‐Shapiro, Anna Bonstein, Lilach Spectre, Galia Atweh, Nardeen Gruenewal, Tsipora Shapiro, Michael Tadmor, Boaz Raanani, Pia |
| description | BACKGROUND
Intravenous immunoglobulin (IVIG) has known efficacy in various hematologic conditions, including immune thrombocytopenic purpura.
STUDY DESIGN AND METHODS
We present the clinical course of a patient with splenic marginal zone lymphoma, who developed acute thrombocytopenia on three consecutive episodes, with nadir counts of 27 × 109, 50 × 109, and 9 × 109/L, upon administration of Intratect IVIG for hypogammaglobulinemia. An immunofluorescence test applying flow cytometry and monoclonal antibody immobilization of platelet antigens (MAIPA) assay were used to evaluate the reaction between IgG present in the IVIG preparations and the patient's or healthy donors' platelets (PLTs).
RESULTS
A strong direct binding reaction was observed between the patient's PLTs and Intratect IgG using both methods. A similar reaction failed to materialize with controls. Binding was not antigen specific according to MAIPA.
CONCLUSIONS
This is the first reported case of thrombocytopenia as a possible adverse effect of IVIG. |
| doi_str_mv | 10.1111/trf.14419 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1971651482</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1971651482</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4199-4616c5e04c5e07e29d58bf36f7ff526bf5c75c164790295fb26d889f4d0c34f43</originalsourceid><addsrcrecordid>eNp10MFKwzAcBvAgipvTgy8gAy966JZ_mrQNnmQ4HQwEmefQpol2tMlMG2U338E39EnM3PQgmMM_lx8fHx9Cp4BHEN64c3oElALfQ31gcRoRztk-6mNMIQKISQ8dte0SY0w4hkPUIxx4DDjuo6uZ6Vz-qoz17bBqGm_sU20LX1fm8_2jMqWXqhzm0ndq2D072xRWrju7UqbKj9GBzutWnez-AXqc3iwmd9H8_nY2uZ5HMlTiEU0gkUxhujmpIrxkWaHjRKdaM5IUmsmUSUhoykM_pguSlFnGNS2xjKmm8QBdbHNXzr541XaiqVqp6jo3KtQWwFNIGNCMBHr-hy6tdya0C4rTlMQJY0FdbpV0tm2d0mLlqiZ3awFYbBYVYVHxvWiwZ7tEXzSq_JU_EwYw3oK3qlbr_5PE4mG6jfwCuiKABA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1994723655</pqid></control><display><type>article</type><title>Intravenous immunoglobulin–induced acute thrombocytopenia</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Gurevich‐Shapiro, Anna ; Bonstein, Lilach ; Spectre, Galia ; Atweh, Nardeen ; Gruenewal, Tsipora ; Shapiro, Michael ; Tadmor, Boaz ; Raanani, Pia</creator><creatorcontrib>Gurevich‐Shapiro, Anna ; Bonstein, Lilach ; Spectre, Galia ; Atweh, Nardeen ; Gruenewal, Tsipora ; Shapiro, Michael ; Tadmor, Boaz ; Raanani, Pia</creatorcontrib><description>BACKGROUND
Intravenous immunoglobulin (IVIG) has known efficacy in various hematologic conditions, including immune thrombocytopenic purpura.
STUDY DESIGN AND METHODS
We present the clinical course of a patient with splenic marginal zone lymphoma, who developed acute thrombocytopenia on three consecutive episodes, with nadir counts of 27 × 109, 50 × 109, and 9 × 109/L, upon administration of Intratect IVIG for hypogammaglobulinemia. An immunofluorescence test applying flow cytometry and monoclonal antibody immobilization of platelet antigens (MAIPA) assay were used to evaluate the reaction between IgG present in the IVIG preparations and the patient's or healthy donors' platelets (PLTs).
RESULTS
A strong direct binding reaction was observed between the patient's PLTs and Intratect IgG using both methods. A similar reaction failed to materialize with controls. Binding was not antigen specific according to MAIPA.
CONCLUSIONS
This is the first reported case of thrombocytopenia as a possible adverse effect of IVIG.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.14419</identifier><identifier>PMID: 29193103</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Agammaglobulinemia - blood ; Agammaglobulinemia - drug therapy ; Aged, 80 and over ; Antigens ; Binding ; Cytometry ; Female ; Flow cytometry ; Humans ; Hypogammaglobulinemia ; Immobilization ; Immunofluorescence ; Immunoglobulin G ; Immunoglobulins ; Immunoglobulins, Intravenous - administration & dosage ; Immunoglobulins, Intravenous - adverse effects ; Intravenous administration ; Lymphoma ; Lymphoma, B-Cell, Marginal Zone - blood ; Lymphoma, B-Cell, Marginal Zone - drug therapy ; Monoclonal antibodies ; Platelets ; Purpura ; Spleen ; Splenic Neoplasms - blood ; Splenic Neoplasms - drug therapy ; Thrombocytopenia ; Thrombocytopenia - blood ; Thrombocytopenia - chemically induced ; Thrombocytopenic purpura</subject><ispartof>Transfusion (Philadelphia, Pa.), 2018-02, Vol.58 (2), p.493-497</ispartof><rights>2017 AABB</rights><rights>2017 AABB.</rights><rights>2018 AABB</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4199-4616c5e04c5e07e29d58bf36f7ff526bf5c75c164790295fb26d889f4d0c34f43</citedby><cites>FETCH-LOGICAL-c4199-4616c5e04c5e07e29d58bf36f7ff526bf5c75c164790295fb26d889f4d0c34f43</cites><orcidid>0000-0001-9698-1306</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29193103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gurevich‐Shapiro, Anna</creatorcontrib><creatorcontrib>Bonstein, Lilach</creatorcontrib><creatorcontrib>Spectre, Galia</creatorcontrib><creatorcontrib>Atweh, Nardeen</creatorcontrib><creatorcontrib>Gruenewal, Tsipora</creatorcontrib><creatorcontrib>Shapiro, Michael</creatorcontrib><creatorcontrib>Tadmor, Boaz</creatorcontrib><creatorcontrib>Raanani, Pia</creatorcontrib><title>Intravenous immunoglobulin–induced acute thrombocytopenia</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND
Intravenous immunoglobulin (IVIG) has known efficacy in various hematologic conditions, including immune thrombocytopenic purpura.
STUDY DESIGN AND METHODS
We present the clinical course of a patient with splenic marginal zone lymphoma, who developed acute thrombocytopenia on three consecutive episodes, with nadir counts of 27 × 109, 50 × 109, and 9 × 109/L, upon administration of Intratect IVIG for hypogammaglobulinemia. An immunofluorescence test applying flow cytometry and monoclonal antibody immobilization of platelet antigens (MAIPA) assay were used to evaluate the reaction between IgG present in the IVIG preparations and the patient's or healthy donors' platelets (PLTs).
RESULTS
A strong direct binding reaction was observed between the patient's PLTs and Intratect IgG using both methods. A similar reaction failed to materialize with controls. Binding was not antigen specific according to MAIPA.
CONCLUSIONS
This is the first reported case of thrombocytopenia as a possible adverse effect of IVIG.</description><subject>Agammaglobulinemia - blood</subject><subject>Agammaglobulinemia - drug therapy</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>Binding</subject><subject>Cytometry</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Humans</subject><subject>Hypogammaglobulinemia</subject><subject>Immobilization</subject><subject>Immunofluorescence</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - administration & dosage</subject><subject>Immunoglobulins, Intravenous - adverse effects</subject><subject>Intravenous administration</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell, Marginal Zone - blood</subject><subject>Lymphoma, B-Cell, Marginal Zone - drug therapy</subject><subject>Monoclonal antibodies</subject><subject>Platelets</subject><subject>Purpura</subject><subject>Spleen</subject><subject>Splenic Neoplasms - blood</subject><subject>Splenic Neoplasms - drug therapy</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - blood</subject><subject>Thrombocytopenia - chemically induced</subject><subject>Thrombocytopenic purpura</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp10MFKwzAcBvAgipvTgy8gAy966JZ_mrQNnmQ4HQwEmefQpol2tMlMG2U338E39EnM3PQgmMM_lx8fHx9Cp4BHEN64c3oElALfQ31gcRoRztk-6mNMIQKISQ8dte0SY0w4hkPUIxx4DDjuo6uZ6Vz-qoz17bBqGm_sU20LX1fm8_2jMqWXqhzm0ndq2D072xRWrju7UqbKj9GBzutWnez-AXqc3iwmd9H8_nY2uZ5HMlTiEU0gkUxhujmpIrxkWaHjRKdaM5IUmsmUSUhoykM_pguSlFnGNS2xjKmm8QBdbHNXzr541XaiqVqp6jo3KtQWwFNIGNCMBHr-hy6tdya0C4rTlMQJY0FdbpV0tm2d0mLlqiZ3awFYbBYVYVHxvWiwZ7tEXzSq_JU_EwYw3oK3qlbr_5PE4mG6jfwCuiKABA</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Gurevich‐Shapiro, Anna</creator><creator>Bonstein, Lilach</creator><creator>Spectre, Galia</creator><creator>Atweh, Nardeen</creator><creator>Gruenewal, Tsipora</creator><creator>Shapiro, Michael</creator><creator>Tadmor, Boaz</creator><creator>Raanani, Pia</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9698-1306</orcidid></search><sort><creationdate>201802</creationdate><title>Intravenous immunoglobulin–induced acute thrombocytopenia</title><author>Gurevich‐Shapiro, Anna ; Bonstein, Lilach ; Spectre, Galia ; Atweh, Nardeen ; Gruenewal, Tsipora ; Shapiro, Michael ; Tadmor, Boaz ; Raanani, Pia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4199-4616c5e04c5e07e29d58bf36f7ff526bf5c75c164790295fb26d889f4d0c34f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Agammaglobulinemia - blood</topic><topic>Agammaglobulinemia - drug therapy</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>Binding</topic><topic>Cytometry</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Humans</topic><topic>Hypogammaglobulinemia</topic><topic>Immobilization</topic><topic>Immunofluorescence</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins, Intravenous - administration & dosage</topic><topic>Immunoglobulins, Intravenous - adverse effects</topic><topic>Intravenous administration</topic><topic>Lymphoma</topic><topic>Lymphoma, B-Cell, Marginal Zone - blood</topic><topic>Lymphoma, B-Cell, Marginal Zone - drug therapy</topic><topic>Monoclonal antibodies</topic><topic>Platelets</topic><topic>Purpura</topic><topic>Spleen</topic><topic>Splenic Neoplasms - blood</topic><topic>Splenic Neoplasms - drug therapy</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - blood</topic><topic>Thrombocytopenia - chemically induced</topic><topic>Thrombocytopenic purpura</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gurevich‐Shapiro, Anna</creatorcontrib><creatorcontrib>Bonstein, Lilach</creatorcontrib><creatorcontrib>Spectre, Galia</creatorcontrib><creatorcontrib>Atweh, Nardeen</creatorcontrib><creatorcontrib>Gruenewal, Tsipora</creatorcontrib><creatorcontrib>Shapiro, Michael</creatorcontrib><creatorcontrib>Tadmor, Boaz</creatorcontrib><creatorcontrib>Raanani, Pia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gurevich‐Shapiro, Anna</au><au>Bonstein, Lilach</au><au>Spectre, Galia</au><au>Atweh, Nardeen</au><au>Gruenewal, Tsipora</au><au>Shapiro, Michael</au><au>Tadmor, Boaz</au><au>Raanani, Pia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous immunoglobulin–induced acute thrombocytopenia</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2018-02</date><risdate>2018</risdate><volume>58</volume><issue>2</issue><spage>493</spage><epage>497</epage><pages>493-497</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>BACKGROUND
Intravenous immunoglobulin (IVIG) has known efficacy in various hematologic conditions, including immune thrombocytopenic purpura.
STUDY DESIGN AND METHODS
We present the clinical course of a patient with splenic marginal zone lymphoma, who developed acute thrombocytopenia on three consecutive episodes, with nadir counts of 27 × 109, 50 × 109, and 9 × 109/L, upon administration of Intratect IVIG for hypogammaglobulinemia. An immunofluorescence test applying flow cytometry and monoclonal antibody immobilization of platelet antigens (MAIPA) assay were used to evaluate the reaction between IgG present in the IVIG preparations and the patient's or healthy donors' platelets (PLTs).
RESULTS
A strong direct binding reaction was observed between the patient's PLTs and Intratect IgG using both methods. A similar reaction failed to materialize with controls. Binding was not antigen specific according to MAIPA.
CONCLUSIONS
This is the first reported case of thrombocytopenia as a possible adverse effect of IVIG.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29193103</pmid><doi>10.1111/trf.14419</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9698-1306</orcidid></addata></record> |
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| ispartof | Transfusion (Philadelphia, Pa.), 2018-02, Vol.58 (2), p.493-497 |
| issn | 0041-1132 1537-2995 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Agammaglobulinemia - blood Agammaglobulinemia - drug therapy Aged, 80 and over Antigens Binding Cytometry Female Flow cytometry Humans Hypogammaglobulinemia Immobilization Immunofluorescence Immunoglobulin G Immunoglobulins Immunoglobulins, Intravenous - administration & dosage Immunoglobulins, Intravenous - adverse effects Intravenous administration Lymphoma Lymphoma, B-Cell, Marginal Zone - blood Lymphoma, B-Cell, Marginal Zone - drug therapy Monoclonal antibodies Platelets Purpura Spleen Splenic Neoplasms - blood Splenic Neoplasms - drug therapy Thrombocytopenia Thrombocytopenia - blood Thrombocytopenia - chemically induced Thrombocytopenic purpura |
| title | Intravenous immunoglobulin–induced acute thrombocytopenia |
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