Lifelong Maintenance of Oral Tolerance and Immunity Profiles in Mice Depends on Early Exposure to Antigen

Oral tolerance is defined as a state of systemic hyporesponsiveness to an antigen that has been previously administered by the oral route. Many factors affect oral tolerance induction; some of them related to antigen, and some related to the animal. The age of the animal is one of the most important...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2018-02, Vol.87 (2), p.73-79
Main Authors: Speziali, E. F., Menezes, J. S., Santiago, A. F., Vaz, N. M., Faria, A. M. C.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antigens
Antigens - immunology
Cell Proliferation
Cells, Cultured
Children
Cytokines - metabolism
Drugs
Environmental Exposure
Female
Humans
Hypersensitivity, Delayed - immunology
Immune response
Immune Tolerance
Immunity, Humoral
Immunization
Immunological tolerance
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mucous membrane
Vaccines
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Summary:Oral tolerance is defined as a state of systemic hyporesponsiveness to an antigen that has been previously administered by the oral route. Many factors affect oral tolerance induction; some of them related to antigen, and some related to the animal. The age of the animal is one of the most important factors that affect oral tolerance as ageing brings many alterations in immune responses. Herein, we demonstrated that both the oral tolerance and pattern of immune reactivity triggered in early life were kept up to 15 months regarding the magnitude of antibody production, cell proliferation and cytokine profile when compared to immune responses induced in old mice. Therefore, our results corroborate with a promising proposal for prevaccination during childhood and young age, and a booster in older age, to make sure that the primary immunization in early life is not lost in aged individuals.
ISSN:0300-9475
1365-3083
DOI:10.1111/sji.12635