Protective effect of aspirin treatment on mouse behavior in the acute phase of experimental infection with Trypanosoma cruzi

Chagas disease is a potentially fatal disease caused by the parasite Trypanosoma cruzi , which can in some cases affect the central nervous system. The objective was to evaluate the effect of aspirin (ASA) in the behavior of mice infected with T. cruzi during the acute phase. This was an experimenta...

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Bibliographic Details
Published in:Parasitology research (1987) 2018, Vol.117 (1), p.189-200
Main Authors: Silvero-Isidre, Arturo, Morínigo-Guayuán, Sergio, Meza-Ojeda, Aaron, Mongelós-Cardozo, Marcelo, Centurión-Wenninger, Claudia, Figueredo-Thiel, Susy, Sanchez, Diego F., Acosta, Nidia
Format: Article
Language:English
Subjects:
Amastigotes
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin
Aspirin - therapeutic use
Behavior, Animal - drug effects
Biomedical and Life Sciences
Biomedicine
Central nervous system
Chagas disease
Chagas Disease - drug therapy
Chagas Disease - mortality
Chagas Disease - parasitology
Data processing
Defecation
Experimental infection
Immunology
Infections
Male
Medical Microbiology
Mice
Mice, Inbred BALB C
Microbiology
Mortality
Open-field behavior
Original Paper
Protective Agents - therapeutic use
Protozoa
Survival analysis
Trypanosoma cruzi
Trypanosoma cruzi - drug effects
Urination
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Summary:Chagas disease is a potentially fatal disease caused by the parasite Trypanosoma cruzi , which can in some cases affect the central nervous system. The objective was to evaluate the effect of aspirin (ASA) in the behavior of mice infected with T. cruzi during the acute phase. This was an experimental study with random assignation. Twenty four BALB/c mice were divided into four groups of six animals each as follows: only ASA (OA), ASA before infection (BI), ASA after infection (AI) and only infection (OI). The strain used for infection was M/HOM/Bra/53/Y. An ASA dose of 100 mg/kg per day was administered 72 h before infection to BI group and the same dose 48 h after infection to AI group. Mice behavior in the open field test, mortality, and brain histopathology was evaluated. Data were analyzed using ANOVA, chi square test, and Kaplan-Meier with long-rank for survival analysis. In the open field test, the OA group has similar results with the BI group, in the variables of immobility and escape. Also, the OA group displayed significantly higher rates of micturition ( p  
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-017-5693-6