Thin Glomerular Basement Membrane in a Kidney Transplant of an Alport's Syndrome Patient: A Case Report

Alport syndrome (AS) and thin basement membrane lesions are caused by various mutations in type IV collagen genes. Although AS is considered a rare disease, thin basement membrane is a frequent pattern, especially in families with a history of persistent hematuria. We report a patient with a diagnos...

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Bibliographic Details
Published in:Transplantation proceedings 2017-12, Vol.49 (10), p.2384-2387
Main Authors: Santos, S., Marques, S., Golper, T., Langone, A., Fogo, A.B.
Format: Article
Language:English
Subjects:
Glomerular Basement Membrane - pathology
Humans
Kidney Transplantation
Male
Nephritis, Hereditary - surgery
Transplants - pathology
Young Adult
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Summary:Alport syndrome (AS) and thin basement membrane lesions are caused by various mutations in type IV collagen genes. Although AS is considered a rare disease, thin basement membrane is a frequent pattern, especially in families with a history of persistent hematuria. We report a patient with a diagnosis of AS who developed end-stage kidney disease (ESKD) and received a kidney transplant from a living unrelated donor. The graft biopsy specimen surprisingly showed a pattern of thin basement membranes. •AS and thin basement membrane lesions are caused by various mutations in type IV collagen genes.•Thin basement membrane lesion affects more than 1% (but 
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2017.07.006