The Role of Autoantibodies in Bone Metabolism and Bone Loss

Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players...

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Bibliographic Details
Published in:Calcified tissue international 2018-05, Vol.102 (5), p.522-532
Main Authors: Hauser, Barbara, Harre, Ulrike
Format: Article
Language:English
Subjects:
Autoantibodies
Autoimmune diseases
Biochemistry
Biomedical and Life Sciences
Bone loss
Bone turnover
Celiac disease
Cell Biology
Citrulline
Endocrinology
Fractures
Homeostasis
Immunoglobulins
Inflammatory diseases
Life Sciences
Metabolism
Orthopedics
Osteoclasts
Osteoprotegerin
Proteins
Quality of life
Review
Rheumatic diseases
Rheumatoid arthritis
Rheumatoid factor
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Description
Summary:Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players of bone homeostasis, in particular osteoclasts. Clinical and pre-clinical studies provide insight into the function of autoantibodies related to Rheumatoid Arthritis (rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies) and their inflammation-independent interaction with bone cells. Furthermore, we summarize the current knowledge about neutralizing antibodies to the antiresorptive protein osteoprotegerin, which have been described in patients with Coeliac Disease, Rheumatoid Arthritis, and Spondyloarthritis.
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-017-0370-4