Total Synthesis of (+)-Gliocladin C Based on One-Pot Construction of a 3a-(3-Indolyl)pyrroloindoline Skeleton by Sulfonium-Mediated Cross-Coupling of Tryptophan and Indole

Total synthesis of (+)-gliocladin C has been achieved on the basis of one-pot construction of the 3a-(3-indolyl)­pyrrolo­indoline core structure by the cross-coupling of a tryptophan derivative and an indole promoted by a sulfonium species generated from dialkylsulfoxide and triflic anhydride.

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Bibliographic Details
Published in:Organic letters 2017-12, Vol.19 (24), p.6582-6585
Main Authors: Tayu, Masanori, Hui, Yi, Takeda, Shiori, Higuchi, Kazuhiro, Saito, Nozomi, Kawasaki, Tomomi
Format: Article
Language:English
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Summary:Total synthesis of (+)-gliocladin C has been achieved on the basis of one-pot construction of the 3a-(3-indolyl)­pyrrolo­indoline core structure by the cross-coupling of a tryptophan derivative and an indole promoted by a sulfonium species generated from dialkylsulfoxide and triflic anhydride.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b03293