Nutritional and hematologic markers as predictors of risk of surgical site infection in patients with head and neck cancer undergoing major oncologic surgery

Background Surgical site infection is a complication of surgery for patients with head and neck cancer. We examined the risk factors for surgical site infection in patients undergoing surgery for head and neck cancer. Methods The study involved 369 patients who underwent surgery for head and neck ca...

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Bibliographic Details
Published in:Head & neck 2018-03, Vol.40 (3), p.596-604
Main Authors: Son, Ho‐Jin, Roh, Jong‐Lyel, Choi, Seung‐Ho, Nam, Soon Yuhl, Kim, Sang Yoon
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Cancer
Female
Head & neck cancer
head and neck cancer
Head and Neck Neoplasms - surgery
Hematology
Humans
Infections
major oncologic surgery
Male
Middle Aged
nutrition
Nutritional Status
Ostomy
Prospective Studies
Radiation therapy
Reconstructive surgery
Risk Factors
Surgery
surgical site infection
Surgical site infections
Surgical Wound Infection - epidemiology
Surgical Wound Infection - etiology
Tracheostomy
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Summary:Background Surgical site infection is a complication of surgery for patients with head and neck cancer. We examined the risk factors for surgical site infection in patients undergoing surgery for head and neck cancer. Methods The study involved 369 patients who underwent surgery for head and neck cancer. Hematological and nutritional parameters were measured preoperatively and postoperatively. Univariate and multivariate analyses were used to determine the risk factors for surgical site infection. Results Of the 369 patients, 104 (28.2%) had surgical site infections: 45 (12.2%) superficial incisional; 6 (1.6%) deep incisional; and 53 (14.4%) organ/space infections. Multivariate analyses showed that history of radiotherapy, weight loss at diagnosis (>5%), preoperative hypoalbuminemia, neutrophil/lymphocyte ratio (NLR), reconstructive surgery, and tracheostomy were the independent factors predictive of surgical site infection. Patients with preoperative low serum albumin levels (
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25031