Membranous glomerulonephritis in chronic lymphocytic leukemia

We present a case of chronic lymphocytic leukemia associated with nephrotic syndrome. Renal biopsy revealed membranous glomerulonephritis accompanied by interstitial monoclonal lymphocytic infiltration. Combination therapy with cyclophosphamide, vincristine, and prednisone (COP) was successful in in...

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Bibliographic Details
Published in:American journal of hematology 2004-07, Vol.76 (3), p.271-274
Main Authors: Ziakas, Panayiotis D., Giannouli, Stavroula, Psimenou, Erasmia, Nakopoulou, Lydia, Voulgarelis, Michalis
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
B-Lymphocytes - immunology
B-Lymphocytes - pathology
Biological and medical sciences
Biopsy
chronic lymphocytic leukemia
Cyclophosphamide - therapeutic use
Glomerulonephritis
Glomerulonephritis, Membranous - complications
Glomerulonephritis, Membranous - pathology
Hematologic and hematopoietic diseases
Humans
Immunophenotyping
Kidney - pathology
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocytes - immunology
Lymphocytes - pathology
Male
Medical sciences
membranous glomerulonephritis
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
nephrotic syndrome
Prednisone - therapeutic use
Proteinuria
Vincristine - therapeutic use
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Description
Summary:We present a case of chronic lymphocytic leukemia associated with nephrotic syndrome. Renal biopsy revealed membranous glomerulonephritis accompanied by interstitial monoclonal lymphocytic infiltration. Combination therapy with cyclophosphamide, vincristine, and prednisone (COP) was successful in inducing an effective response in chronic lymphocytic leukemia. Improvement of renal function and proteinuria was also observed. Am. J. Hematol. 76:271–274, 2004. © 2004 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.20109