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CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma
Barrett's esophagus represents an early stage in carcinogenesis leading to esophageal adenocarcinoma. Considerable evidence supports a major role for chronic inflammation and diverse chemokine pathways in the development of Barrett's esophagus and esophageal adenocarcinoma. Here we utilize...
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| Published in: | Clinical cancer research 2018-03, Vol.24 (5), p.1048-1061 |
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| creator | Fang, Hsin-Yu Münch, Natasha Stephens Schottelius, Margret Ingermann, Jonas Liu, Haibo Schauer, Michael Stangl, Stefan Multhoff, Gabriele Steiger, Katja Gerngroß, Carlos Jesinghaus, Moritz Weichert, Wilko Kühl, Anja A Sepulveda, Antonia R Wester, Hans-Jürgen Wang, Timothy C Quante, Michael |
| description | Barrett's esophagus represents an early stage in carcinogenesis leading to esophageal adenocarcinoma. Considerable evidence supports a major role for chronic inflammation and diverse chemokine pathways in the development of Barrett's esophagus and esophageal adenocarcinoma.
Here we utilized an
transgenic mouse model of Barrett's esophagus and esophageal adenocarcinoma and human patient imaging to analyze the importance of CXCR4-expressing cells during esophageal carcinogenesis.
IL1β overexpression induces chronic esophageal inflammation and recapitulates the progression to Barrett's esophagus and esophageal adenocarcinoma. CXCR4 expression is increased in both epithelial and immune cells during disease progression in pL2-IL1β mice and also elevated in esophageal adenocarcinoma patient biopsy samples. Specific recruitment of CXCR4-positive (CXCR4
) immune cells correlated with dysplasia progression, suggesting that this immune population may be a key contributor to esophageal carcinogenesis. Similarly, with progression to dysplasia, there were increased numbers of CXCR4
columnar epithelial cells at the squamocolumnar junction (SCJ). These findings were supported by stronger CXCR4-related signal intensity in
fluorescence imaging and autoradiography with advanced dysplasia. Pilot CXCR4-directed PET/CT imaging studies in patients with esophageal cancer demonstrate the potential utility of CXCR4 imaging for the diagnosis and staging of esophageal cancer.
In conclusion, the recruitment of CXCR4
immune cells and expansion of CXCR4
epithelial cells in esophageal dysplasia and cancer highlight the potential of CXCR4 as a biomarker and molecular target for diagnostic imaging of the tumor microenvironment in esophageal adenocarcinoma.
. |
| doi_str_mv | 10.1158/1078-0432.ccr-17-1756 |
| format | article |
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Here we utilized an
transgenic mouse model of Barrett's esophagus and esophageal adenocarcinoma and human patient imaging to analyze the importance of CXCR4-expressing cells during esophageal carcinogenesis.
IL1β overexpression induces chronic esophageal inflammation and recapitulates the progression to Barrett's esophagus and esophageal adenocarcinoma. CXCR4 expression is increased in both epithelial and immune cells during disease progression in pL2-IL1β mice and also elevated in esophageal adenocarcinoma patient biopsy samples. Specific recruitment of CXCR4-positive (CXCR4
) immune cells correlated with dysplasia progression, suggesting that this immune population may be a key contributor to esophageal carcinogenesis. Similarly, with progression to dysplasia, there were increased numbers of CXCR4
columnar epithelial cells at the squamocolumnar junction (SCJ). These findings were supported by stronger CXCR4-related signal intensity in
fluorescence imaging and autoradiography with advanced dysplasia. Pilot CXCR4-directed PET/CT imaging studies in patients with esophageal cancer demonstrate the potential utility of CXCR4 imaging for the diagnosis and staging of esophageal cancer.
In conclusion, the recruitment of CXCR4
immune cells and expansion of CXCR4
epithelial cells in esophageal dysplasia and cancer highlight the potential of CXCR4 as a biomarker and molecular target for diagnostic imaging of the tumor microenvironment in esophageal adenocarcinoma.
.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.ccr-17-1756</identifier><identifier>PMID: 29208671</identifier><language>eng</language><publisher>United States: American Association for Cancer Research Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - immunology ; Adenocarcinoma - pathology ; Aged ; Aged, 80 and over ; Animals ; Autoradiography ; Barrett Esophagus - diagnostic imaging ; Barrett Esophagus - immunology ; Barrett Esophagus - pathology ; Barrett's esophagus ; Biomarkers ; Biomarkers, Tumor - immunology ; Biomarkers, Tumor - metabolism ; Biopsy ; Cancer ; Carcinogenesis ; Carcinogenesis - pathology ; Carcinogens ; Computed tomography ; Coordination Complexes - administration & dosage ; CXCR4 protein ; Diagnostic systems ; Disease Models, Animal ; Disease Progression ; Dysplasia ; Epithelial cells ; Esophageal cancer ; Esophageal Neoplasms - diagnostic imaging ; Esophageal Neoplasms - immunology ; Esophageal Neoplasms - pathology ; Esophagus ; Esophagus - immunology ; Esophagus - pathology ; Experimental design ; Fluorescence ; Health risk assessment ; Humans ; Imaging ; Immune system ; Interleukin 1 ; Interleukin-1beta - genetics ; Interleukin-1beta - metabolism ; Mice, Transgenic ; Middle Aged ; Molecular Imaging - methods ; Peptides, Cyclic - administration & dosage ; Positron emission ; Positron Emission Tomography Computed Tomography - methods ; Receptors, CXCR4 - immunology ; Receptors, CXCR4 - metabolism ; Target recognition ; Tissue Array Analysis ; Tomography ; Transgenic mice ; Tumor Microenvironment - immunology ; Up-Regulation</subject><ispartof>Clinical cancer research, 2018-03, Vol.24 (5), p.1048-1061</ispartof><rights>2017 American Association for Cancer Research.</rights><rights>Copyright American Association for Cancer Research Inc Mar 1, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-f1dbd1207f546d292f57446cbb14dd5e7429e00a467f9d3070a1fe61102f42b73</citedby><cites>FETCH-LOGICAL-c450t-f1dbd1207f546d292f57446cbb14dd5e7429e00a467f9d3070a1fe61102f42b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29208671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Hsin-Yu</creatorcontrib><creatorcontrib>Münch, Natasha Stephens</creatorcontrib><creatorcontrib>Schottelius, Margret</creatorcontrib><creatorcontrib>Ingermann, Jonas</creatorcontrib><creatorcontrib>Liu, Haibo</creatorcontrib><creatorcontrib>Schauer, Michael</creatorcontrib><creatorcontrib>Stangl, Stefan</creatorcontrib><creatorcontrib>Multhoff, Gabriele</creatorcontrib><creatorcontrib>Steiger, Katja</creatorcontrib><creatorcontrib>Gerngroß, Carlos</creatorcontrib><creatorcontrib>Jesinghaus, Moritz</creatorcontrib><creatorcontrib>Weichert, Wilko</creatorcontrib><creatorcontrib>Kühl, Anja A</creatorcontrib><creatorcontrib>Sepulveda, Antonia R</creatorcontrib><creatorcontrib>Wester, Hans-Jürgen</creatorcontrib><creatorcontrib>Wang, Timothy C</creatorcontrib><creatorcontrib>Quante, Michael</creatorcontrib><title>CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Barrett's esophagus represents an early stage in carcinogenesis leading to esophageal adenocarcinoma. Considerable evidence supports a major role for chronic inflammation and diverse chemokine pathways in the development of Barrett's esophagus and esophageal adenocarcinoma.
Here we utilized an
transgenic mouse model of Barrett's esophagus and esophageal adenocarcinoma and human patient imaging to analyze the importance of CXCR4-expressing cells during esophageal carcinogenesis.
IL1β overexpression induces chronic esophageal inflammation and recapitulates the progression to Barrett's esophagus and esophageal adenocarcinoma. CXCR4 expression is increased in both epithelial and immune cells during disease progression in pL2-IL1β mice and also elevated in esophageal adenocarcinoma patient biopsy samples. Specific recruitment of CXCR4-positive (CXCR4
) immune cells correlated with dysplasia progression, suggesting that this immune population may be a key contributor to esophageal carcinogenesis. Similarly, with progression to dysplasia, there were increased numbers of CXCR4
columnar epithelial cells at the squamocolumnar junction (SCJ). These findings were supported by stronger CXCR4-related signal intensity in
fluorescence imaging and autoradiography with advanced dysplasia. Pilot CXCR4-directed PET/CT imaging studies in patients with esophageal cancer demonstrate the potential utility of CXCR4 imaging for the diagnosis and staging of esophageal cancer.
In conclusion, the recruitment of CXCR4
immune cells and expansion of CXCR4
epithelial cells in esophageal dysplasia and cancer highlight the potential of CXCR4 as a biomarker and molecular target for diagnostic imaging of the tumor microenvironment in esophageal adenocarcinoma.
.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - immunology</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Autoradiography</subject><subject>Barrett Esophagus - diagnostic imaging</subject><subject>Barrett Esophagus - immunology</subject><subject>Barrett Esophagus - pathology</subject><subject>Barrett's esophagus</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - immunology</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogenesis - pathology</subject><subject>Carcinogens</subject><subject>Computed tomography</subject><subject>Coordination Complexes - administration & dosage</subject><subject>CXCR4 protein</subject><subject>Diagnostic systems</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Dysplasia</subject><subject>Epithelial cells</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - diagnostic imaging</subject><subject>Esophageal Neoplasms - immunology</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagus</subject><subject>Esophagus - immunology</subject><subject>Esophagus - pathology</subject><subject>Experimental design</subject><subject>Fluorescence</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Imaging</subject><subject>Immune system</subject><subject>Interleukin 1</subject><subject>Interleukin-1beta - genetics</subject><subject>Interleukin-1beta - metabolism</subject><subject>Mice, Transgenic</subject><subject>Middle Aged</subject><subject>Molecular Imaging - methods</subject><subject>Peptides, Cyclic - administration & dosage</subject><subject>Positron emission</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Receptors, CXCR4 - immunology</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Target recognition</subject><subject>Tissue Array Analysis</subject><subject>Tomography</subject><subject>Transgenic mice</subject><subject>Tumor Microenvironment - immunology</subject><subject>Up-Regulation</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkUtr3DAUhUVJaR7tT2gQZJFunOjKetjLxJm0A4GGMIXuhKyHq2BLE8mzmH9fD0m6KFy4d_Gdw-UchL4CuQLgzTUQ2VSE1fTKmFyBXIaLD-gEOJdVTQU_Wu535hidlvJMCDAg7BM6pi0ljZBwgmL3u3tieF2wxo9pdnEOesQbnQc3Y58yvgt6iKnMweDH1ea62-D1pIcQBxwivtU5u3m-LPhuX7ajLkFjHS1elbT9owe3WN1YF5PR2YSYJv0ZffR6LO7L2z5Dv-5Xm-5H9fDz-7q7eagM42SuPNjeAiXScybs8q3nkjFh-h6YtdxJRltHiGZC-tbWRBIN3gkAQj2jvazP0LdX321OLztXZjWFYtw46ujSrihoZc24oLxd0Iv_0Oe0y3H5TlECUIumqWGh-CtlciolO6-2OUw67xUQdShEHcJWh7BV1z0pkOpQyKI7f3Pf9ZOz_1TvDdR_AdKAhIQ</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Fang, Hsin-Yu</creator><creator>Münch, Natasha Stephens</creator><creator>Schottelius, Margret</creator><creator>Ingermann, Jonas</creator><creator>Liu, Haibo</creator><creator>Schauer, Michael</creator><creator>Stangl, Stefan</creator><creator>Multhoff, Gabriele</creator><creator>Steiger, Katja</creator><creator>Gerngroß, Carlos</creator><creator>Jesinghaus, Moritz</creator><creator>Weichert, Wilko</creator><creator>Kühl, Anja A</creator><creator>Sepulveda, Antonia R</creator><creator>Wester, Hans-Jürgen</creator><creator>Wang, Timothy C</creator><creator>Quante, Michael</creator><general>American Association for Cancer Research Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma</title><author>Fang, Hsin-Yu ; Münch, Natasha Stephens ; Schottelius, Margret ; Ingermann, Jonas ; Liu, Haibo ; Schauer, Michael ; Stangl, Stefan ; Multhoff, Gabriele ; Steiger, Katja ; Gerngroß, Carlos ; Jesinghaus, Moritz ; Weichert, Wilko ; Kühl, Anja A ; Sepulveda, Antonia R ; Wester, Hans-Jürgen ; Wang, Timothy C ; Quante, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-f1dbd1207f546d292f57446cbb14dd5e7429e00a467f9d3070a1fe61102f42b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - immunology</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Autoradiography</topic><topic>Barrett Esophagus - diagnostic imaging</topic><topic>Barrett Esophagus - immunology</topic><topic>Barrett Esophagus - pathology</topic><topic>Barrett's esophagus</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - immunology</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogenesis - pathology</topic><topic>Carcinogens</topic><topic>Computed tomography</topic><topic>Coordination Complexes - administration & dosage</topic><topic>CXCR4 protein</topic><topic>Diagnostic systems</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Dysplasia</topic><topic>Epithelial cells</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - diagnostic imaging</topic><topic>Esophageal Neoplasms - immunology</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagus</topic><topic>Esophagus - immunology</topic><topic>Esophagus - pathology</topic><topic>Experimental design</topic><topic>Fluorescence</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Imaging</topic><topic>Immune system</topic><topic>Interleukin 1</topic><topic>Interleukin-1beta - genetics</topic><topic>Interleukin-1beta - metabolism</topic><topic>Mice, Transgenic</topic><topic>Middle Aged</topic><topic>Molecular Imaging - methods</topic><topic>Peptides, Cyclic - administration & dosage</topic><topic>Positron emission</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Receptors, CXCR4 - immunology</topic><topic>Receptors, CXCR4 - metabolism</topic><topic>Target recognition</topic><topic>Tissue Array Analysis</topic><topic>Tomography</topic><topic>Transgenic mice</topic><topic>Tumor Microenvironment - immunology</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Hsin-Yu</creatorcontrib><creatorcontrib>Münch, Natasha Stephens</creatorcontrib><creatorcontrib>Schottelius, Margret</creatorcontrib><creatorcontrib>Ingermann, Jonas</creatorcontrib><creatorcontrib>Liu, Haibo</creatorcontrib><creatorcontrib>Schauer, Michael</creatorcontrib><creatorcontrib>Stangl, Stefan</creatorcontrib><creatorcontrib>Multhoff, Gabriele</creatorcontrib><creatorcontrib>Steiger, Katja</creatorcontrib><creatorcontrib>Gerngroß, Carlos</creatorcontrib><creatorcontrib>Jesinghaus, Moritz</creatorcontrib><creatorcontrib>Weichert, Wilko</creatorcontrib><creatorcontrib>Kühl, Anja A</creatorcontrib><creatorcontrib>Sepulveda, Antonia R</creatorcontrib><creatorcontrib>Wester, Hans-Jürgen</creatorcontrib><creatorcontrib>Wang, Timothy C</creatorcontrib><creatorcontrib>Quante, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Hsin-Yu</au><au>Münch, Natasha Stephens</au><au>Schottelius, Margret</au><au>Ingermann, Jonas</au><au>Liu, Haibo</au><au>Schauer, Michael</au><au>Stangl, Stefan</au><au>Multhoff, Gabriele</au><au>Steiger, Katja</au><au>Gerngroß, Carlos</au><au>Jesinghaus, Moritz</au><au>Weichert, Wilko</au><au>Kühl, Anja A</au><au>Sepulveda, Antonia R</au><au>Wester, Hans-Jürgen</au><au>Wang, Timothy C</au><au>Quante, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>24</volume><issue>5</issue><spage>1048</spage><epage>1061</epage><pages>1048-1061</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Barrett's esophagus represents an early stage in carcinogenesis leading to esophageal adenocarcinoma. Considerable evidence supports a major role for chronic inflammation and diverse chemokine pathways in the development of Barrett's esophagus and esophageal adenocarcinoma.
Here we utilized an
transgenic mouse model of Barrett's esophagus and esophageal adenocarcinoma and human patient imaging to analyze the importance of CXCR4-expressing cells during esophageal carcinogenesis.
IL1β overexpression induces chronic esophageal inflammation and recapitulates the progression to Barrett's esophagus and esophageal adenocarcinoma. CXCR4 expression is increased in both epithelial and immune cells during disease progression in pL2-IL1β mice and also elevated in esophageal adenocarcinoma patient biopsy samples. Specific recruitment of CXCR4-positive (CXCR4
) immune cells correlated with dysplasia progression, suggesting that this immune population may be a key contributor to esophageal carcinogenesis. Similarly, with progression to dysplasia, there were increased numbers of CXCR4
columnar epithelial cells at the squamocolumnar junction (SCJ). These findings were supported by stronger CXCR4-related signal intensity in
fluorescence imaging and autoradiography with advanced dysplasia. Pilot CXCR4-directed PET/CT imaging studies in patients with esophageal cancer demonstrate the potential utility of CXCR4 imaging for the diagnosis and staging of esophageal cancer.
In conclusion, the recruitment of CXCR4
immune cells and expansion of CXCR4
epithelial cells in esophageal dysplasia and cancer highlight the potential of CXCR4 as a biomarker and molecular target for diagnostic imaging of the tumor microenvironment in esophageal adenocarcinoma.
.</abstract><cop>United States</cop><pub>American Association for Cancer Research Inc</pub><pmid>29208671</pmid><doi>10.1158/1078-0432.ccr-17-1756</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical cancer research, 2018-03, Vol.24 (5), p.1048-1061 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1973456259 |
| source | Freely Accessible Science Journals at publisher websites |
| subjects | Adenocarcinoma Adenocarcinoma - diagnostic imaging Adenocarcinoma - immunology Adenocarcinoma - pathology Aged Aged, 80 and over Animals Autoradiography Barrett Esophagus - diagnostic imaging Barrett Esophagus - immunology Barrett Esophagus - pathology Barrett's esophagus Biomarkers Biomarkers, Tumor - immunology Biomarkers, Tumor - metabolism Biopsy Cancer Carcinogenesis Carcinogenesis - pathology Carcinogens Computed tomography Coordination Complexes - administration & dosage CXCR4 protein Diagnostic systems Disease Models, Animal Disease Progression Dysplasia Epithelial cells Esophageal cancer Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - immunology Esophageal Neoplasms - pathology Esophagus Esophagus - immunology Esophagus - pathology Experimental design Fluorescence Health risk assessment Humans Imaging Immune system Interleukin 1 Interleukin-1beta - genetics Interleukin-1beta - metabolism Mice, Transgenic Middle Aged Molecular Imaging - methods Peptides, Cyclic - administration & dosage Positron emission Positron Emission Tomography Computed Tomography - methods Receptors, CXCR4 - immunology Receptors, CXCR4 - metabolism Target recognition Tissue Array Analysis Tomography Transgenic mice Tumor Microenvironment - immunology Up-Regulation |
| title | CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma |
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