Ni–Al Bimetallic Catalyzed Enantioselective Cycloaddition of Cyclopropyl Carboxamide with Alkyne

A Ni–Al bimetallic catalyzed enantioselective cycloaddition reaction of cyclopropyl carboxamides with alkynes has been developed. A series of cyclopentenyl carboxamides were obtained in up to 99% yield and 94% ee. The bifunctional-ligand-enabled bimetallic catalysis proved to be an efficient strateg...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2017-12, Vol.139 (50), p.18150-18153
Main Authors: Liu, Qi-Sheng, Wang, De-Yin, Yang, Zhi-Jun, Luan, Yu-Xin, Yang, Jin-Fei, Li, Jiang-Fei, Pu, You-Ge, Ye, Mengchun
Format: Article
Language:English
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Summary:A Ni–Al bimetallic catalyzed enantioselective cycloaddition reaction of cyclopropyl carboxamides with alkynes has been developed. A series of cyclopentenyl carboxamides were obtained in up to 99% yield and 94% ee. The bifunctional-ligand-enabled bimetallic catalysis proved to be an efficient strategy for the C–C bond cleavage of unreactive cyclopropanes.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.7b09947