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Urinary C-megalin for screening of renal scarring in children after febrile urinary tract infection
Background Febrile urinary tract infection (fUTI) in children may cause renal scarring. This study aimed to investigate the usefulness of urinary biomarkers for diagnosing renal scarring after fUTI. Methods Thirty-seven children (median age: 1.36 years, range: 0.52–12.17 years, 25 boys) with a histo...
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| Published in: | Pediatric research 2018-03, Vol.83 (3), p.662-668 |
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| container_end_page | 668 |
| container_issue | 3 |
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| container_title | Pediatric research |
| container_volume | 83 |
| creator | Yamanouchi, Sohsaku Kimata, Takahisa Kino, Jiro Kitao, Tetsuya Suruda, Chikushi Tsuji, Shoji Kurosawa, Hiroyuki Hirayama, Yoshiaki Saito, Akihiko Kaneko, Kazunari |
| description | Background
Febrile urinary tract infection (fUTI) in children may cause renal scarring. This study aimed to investigate the usefulness of urinary biomarkers for diagnosing renal scarring after fUTI.
Methods
Thirty-seven children (median age: 1.36 years, range: 0.52–12.17 years, 25 boys) with a history of fUTI, who underwent renal scintigraphy for 4 months or longer after the last episode of fUTI, were analyzed. A spot urine sample was obtained on the day of renal scintigraphy to measure levels of total protein,
N
-acetyl-β-
D
-glucosaminidase (NAG), β
2
-microglobulin (BMG), neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP), and C-megalin (full-length megalin). Results were corrected for urinary creatinine (Cr) and compared between the group with renal scarring (
n
=23) and that without scarring (
n
=14). Urinary levels of C-megalin were also measured in healthy control subjects.
Results
No significant differences in total protein, NGAL, L-FABP, NAG, and BMG levels were found between the groups. However, C-megalin levels were significantly higher in the renal scarring group than in the non-renal scarring group and healthy controls (
P |
| doi_str_mv | 10.1038/pr.2017.276 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1973459487</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2608620639</sourcerecordid><originalsourceid>FETCH-LOGICAL-c513t-140af7197412883146397b01bf61b6bb4c4d13ab85f837382ca7e6d76e62e4be3</originalsourceid><addsrcrecordid>eNp9kUFrFDEUgIModls9eZcBL0Kd9b0kk2SOZbFVKPTSnock-1KnzM6sLzMH_71ZdlUQ6Snk8fE9kk-IdwhrBOU-73ktAe1aWvNCrLBRUIPW9qVYASisVdu6M3Ge8xMA6sbp1-JMthIRmmYl4gP3o-ef1abe0aMf-rFKE1c5MtHYj4_VlCqm0Q9l5JkPk4LE7_2wLePKp5m4ShS4H6haTq6ZfZwLlyjO_TS-Ea-SHzK9PZ0X4uH6y_3ma317d_Ntc3VbxwbVXKMGnyy2VqN0TqE2qrUBMCSDwYSgo96i8sE1ySmrnIzektlaQ0aSDqQuxMejd8_Tj4Xy3O36HGkY_EjTkruiVrpptbMF_fAP-jQtXJ6ZO2nAGQll-bOUUgCNlfZ5F8iSA2XrCnV5pCJPOTOlbs_9rvxWh9AdOpZ7d-jYlY6Ffn9yLmFH2z_s73AF-HQE8v4Qhfjv0v_5fgGDE6Q5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2025301298</pqid></control><display><type>article</type><title>Urinary C-megalin for screening of renal scarring in children after febrile urinary tract infection</title><source>Springer Link</source><creator>Yamanouchi, Sohsaku ; Kimata, Takahisa ; Kino, Jiro ; Kitao, Tetsuya ; Suruda, Chikushi ; Tsuji, Shoji ; Kurosawa, Hiroyuki ; Hirayama, Yoshiaki ; Saito, Akihiko ; Kaneko, Kazunari</creator><creatorcontrib>Yamanouchi, Sohsaku ; Kimata, Takahisa ; Kino, Jiro ; Kitao, Tetsuya ; Suruda, Chikushi ; Tsuji, Shoji ; Kurosawa, Hiroyuki ; Hirayama, Yoshiaki ; Saito, Akihiko ; Kaneko, Kazunari</creatorcontrib><description>Background
Febrile urinary tract infection (fUTI) in children may cause renal scarring. This study aimed to investigate the usefulness of urinary biomarkers for diagnosing renal scarring after fUTI.
Methods
Thirty-seven children (median age: 1.36 years, range: 0.52–12.17 years, 25 boys) with a history of fUTI, who underwent renal scintigraphy for 4 months or longer after the last episode of fUTI, were analyzed. A spot urine sample was obtained on the day of renal scintigraphy to measure levels of total protein,
N
-acetyl-β-
D
-glucosaminidase (NAG), β
2
-microglobulin (BMG), neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP), and C-megalin (full-length megalin). Results were corrected for urinary creatinine (Cr) and compared between the group with renal scarring (
n
=23) and that without scarring (
n
=14). Urinary levels of C-megalin were also measured in healthy control subjects.
Results
No significant differences in total protein, NGAL, L-FABP, NAG, and BMG levels were found between the groups. However, C-megalin levels were significantly higher in the renal scarring group than in the non-renal scarring group and healthy controls (
P
<0.001). A cutoff value of 6.5 pmol/nmol of urinary C-megalin/Cr yielded 73.9% of specificity and 92.9% of sensitivity.
Conclusion
Urinary C-megalin is useful for diagnosing renal scarring caused by fUTI.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2017.276</identifier><identifier>PMID: 29211055</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/4022/1585 ; 692/53/2421 ; 692/699/2768/1865 ; 692/700/1720/3187 ; Acetylglucosaminidase - urine ; beta 2-Microglobulin - urine ; Biomarkers - urine ; Case-Control Studies ; Child ; Child, Preschool ; Children & youth ; clinical-investigation ; Creatinine - urine ; Fatty Acid-Binding Proteins - urine ; Female ; Fever - complications ; Fever - urine ; Humans ; Infant ; Kidney - diagnostic imaging ; Kidney - injuries ; Kidney Diseases - diagnostic imaging ; Kidney Diseases - etiology ; Kidney Diseases - urine ; Kidneys ; Lipocalin-2 - urine ; Low Density Lipoprotein Receptor-Related Protein-2 - analysis ; Male ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Proteins ; Radionuclide Imaging ; Risk Factors ; Scars ; Scintigraphy ; Sensitivity and Specificity ; Urinalysis - methods ; Urinary tract diseases ; Urinary tract infections ; Urinary Tract Infections - complications ; Urinary Tract Infections - urine ; Urogenital system</subject><ispartof>Pediatric research, 2018-03, Vol.83 (3), p.662-668</ispartof><rights>International Pediatric Research Foundation, Inc. 2018</rights><rights>Copyright Nature Publishing Group Mar 2018</rights><rights>International Pediatric Research Foundation, Inc. 2018.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-140af7197412883146397b01bf61b6bb4c4d13ab85f837382ca7e6d76e62e4be3</citedby><cites>FETCH-LOGICAL-c513t-140af7197412883146397b01bf61b6bb4c4d13ab85f837382ca7e6d76e62e4be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29211055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamanouchi, Sohsaku</creatorcontrib><creatorcontrib>Kimata, Takahisa</creatorcontrib><creatorcontrib>Kino, Jiro</creatorcontrib><creatorcontrib>Kitao, Tetsuya</creatorcontrib><creatorcontrib>Suruda, Chikushi</creatorcontrib><creatorcontrib>Tsuji, Shoji</creatorcontrib><creatorcontrib>Kurosawa, Hiroyuki</creatorcontrib><creatorcontrib>Hirayama, Yoshiaki</creatorcontrib><creatorcontrib>Saito, Akihiko</creatorcontrib><creatorcontrib>Kaneko, Kazunari</creatorcontrib><title>Urinary C-megalin for screening of renal scarring in children after febrile urinary tract infection</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Febrile urinary tract infection (fUTI) in children may cause renal scarring. This study aimed to investigate the usefulness of urinary biomarkers for diagnosing renal scarring after fUTI.
Methods
Thirty-seven children (median age: 1.36 years, range: 0.52–12.17 years, 25 boys) with a history of fUTI, who underwent renal scintigraphy for 4 months or longer after the last episode of fUTI, were analyzed. A spot urine sample was obtained on the day of renal scintigraphy to measure levels of total protein,
N
-acetyl-β-
D
-glucosaminidase (NAG), β
2
-microglobulin (BMG), neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP), and C-megalin (full-length megalin). Results were corrected for urinary creatinine (Cr) and compared between the group with renal scarring (
n
=23) and that without scarring (
n
=14). Urinary levels of C-megalin were also measured in healthy control subjects.
Results
No significant differences in total protein, NGAL, L-FABP, NAG, and BMG levels were found between the groups. However, C-megalin levels were significantly higher in the renal scarring group than in the non-renal scarring group and healthy controls (
P
<0.001). A cutoff value of 6.5 pmol/nmol of urinary C-megalin/Cr yielded 73.9% of specificity and 92.9% of sensitivity.
Conclusion
Urinary C-megalin is useful for diagnosing renal scarring caused by fUTI.</description><subject>692/4022/1585</subject><subject>692/53/2421</subject><subject>692/699/2768/1865</subject><subject>692/700/1720/3187</subject><subject>Acetylglucosaminidase - urine</subject><subject>beta 2-Microglobulin - urine</subject><subject>Biomarkers - urine</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>clinical-investigation</subject><subject>Creatinine - urine</subject><subject>Fatty Acid-Binding Proteins - urine</subject><subject>Female</subject><subject>Fever - complications</subject><subject>Fever - urine</subject><subject>Humans</subject><subject>Infant</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - injuries</subject><subject>Kidney Diseases - diagnostic imaging</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Diseases - urine</subject><subject>Kidneys</subject><subject>Lipocalin-2 - urine</subject><subject>Low Density Lipoprotein Receptor-Related Protein-2 - analysis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Proteins</subject><subject>Radionuclide Imaging</subject><subject>Risk Factors</subject><subject>Scars</subject><subject>Scintigraphy</subject><subject>Sensitivity and Specificity</subject><subject>Urinalysis - methods</subject><subject>Urinary tract diseases</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - complications</subject><subject>Urinary Tract Infections - urine</subject><subject>Urogenital system</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kUFrFDEUgIModls9eZcBL0Kd9b0kk2SOZbFVKPTSnock-1KnzM6sLzMH_71ZdlUQ6Snk8fE9kk-IdwhrBOU-73ktAe1aWvNCrLBRUIPW9qVYASisVdu6M3Ge8xMA6sbp1-JMthIRmmYl4gP3o-ef1abe0aMf-rFKE1c5MtHYj4_VlCqm0Q9l5JkPk4LE7_2wLePKp5m4ShS4H6haTq6ZfZwLlyjO_TS-Ea-SHzK9PZ0X4uH6y_3ma317d_Ntc3VbxwbVXKMGnyy2VqN0TqE2qrUBMCSDwYSgo96i8sE1ySmrnIzektlaQ0aSDqQuxMejd8_Tj4Xy3O36HGkY_EjTkruiVrpptbMF_fAP-jQtXJ6ZO2nAGQll-bOUUgCNlfZ5F8iSA2XrCnV5pCJPOTOlbs_9rvxWh9AdOpZ7d-jYlY6Ffn9yLmFH2z_s73AF-HQE8v4Qhfjv0v_5fgGDE6Q5</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Yamanouchi, Sohsaku</creator><creator>Kimata, Takahisa</creator><creator>Kino, Jiro</creator><creator>Kitao, Tetsuya</creator><creator>Suruda, Chikushi</creator><creator>Tsuji, Shoji</creator><creator>Kurosawa, Hiroyuki</creator><creator>Hirayama, Yoshiaki</creator><creator>Saito, Akihiko</creator><creator>Kaneko, Kazunari</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Urinary C-megalin for screening of renal scarring in children after febrile urinary tract infection</title><author>Yamanouchi, Sohsaku ; Kimata, Takahisa ; Kino, Jiro ; Kitao, Tetsuya ; Suruda, Chikushi ; Tsuji, Shoji ; Kurosawa, Hiroyuki ; Hirayama, Yoshiaki ; Saito, Akihiko ; Kaneko, Kazunari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-140af7197412883146397b01bf61b6bb4c4d13ab85f837382ca7e6d76e62e4be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/4022/1585</topic><topic>692/53/2421</topic><topic>692/699/2768/1865</topic><topic>692/700/1720/3187</topic><topic>Acetylglucosaminidase - urine</topic><topic>beta 2-Microglobulin - urine</topic><topic>Biomarkers - urine</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>clinical-investigation</topic><topic>Creatinine - urine</topic><topic>Fatty Acid-Binding Proteins - urine</topic><topic>Female</topic><topic>Fever - complications</topic><topic>Fever - urine</topic><topic>Humans</topic><topic>Infant</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - injuries</topic><topic>Kidney Diseases - diagnostic imaging</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Diseases - urine</topic><topic>Kidneys</topic><topic>Lipocalin-2 - urine</topic><topic>Low Density Lipoprotein Receptor-Related Protein-2 - analysis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Proteins</topic><topic>Radionuclide Imaging</topic><topic>Risk Factors</topic><topic>Scars</topic><topic>Scintigraphy</topic><topic>Sensitivity and Specificity</topic><topic>Urinalysis - methods</topic><topic>Urinary tract diseases</topic><topic>Urinary tract infections</topic><topic>Urinary Tract Infections - complications</topic><topic>Urinary Tract Infections - urine</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamanouchi, Sohsaku</creatorcontrib><creatorcontrib>Kimata, Takahisa</creatorcontrib><creatorcontrib>Kino, Jiro</creatorcontrib><creatorcontrib>Kitao, Tetsuya</creatorcontrib><creatorcontrib>Suruda, Chikushi</creatorcontrib><creatorcontrib>Tsuji, Shoji</creatorcontrib><creatorcontrib>Kurosawa, Hiroyuki</creatorcontrib><creatorcontrib>Hirayama, Yoshiaki</creatorcontrib><creatorcontrib>Saito, Akihiko</creatorcontrib><creatorcontrib>Kaneko, Kazunari</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamanouchi, Sohsaku</au><au>Kimata, Takahisa</au><au>Kino, Jiro</au><au>Kitao, Tetsuya</au><au>Suruda, Chikushi</au><au>Tsuji, Shoji</au><au>Kurosawa, Hiroyuki</au><au>Hirayama, Yoshiaki</au><au>Saito, Akihiko</au><au>Kaneko, Kazunari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary C-megalin for screening of renal scarring in children after febrile urinary tract infection</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>83</volume><issue>3</issue><spage>662</spage><epage>668</epage><pages>662-668</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Febrile urinary tract infection (fUTI) in children may cause renal scarring. This study aimed to investigate the usefulness of urinary biomarkers for diagnosing renal scarring after fUTI.
Methods
Thirty-seven children (median age: 1.36 years, range: 0.52–12.17 years, 25 boys) with a history of fUTI, who underwent renal scintigraphy for 4 months or longer after the last episode of fUTI, were analyzed. A spot urine sample was obtained on the day of renal scintigraphy to measure levels of total protein,
N
-acetyl-β-
D
-glucosaminidase (NAG), β
2
-microglobulin (BMG), neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP), and C-megalin (full-length megalin). Results were corrected for urinary creatinine (Cr) and compared between the group with renal scarring (
n
=23) and that without scarring (
n
=14). Urinary levels of C-megalin were also measured in healthy control subjects.
Results
No significant differences in total protein, NGAL, L-FABP, NAG, and BMG levels were found between the groups. However, C-megalin levels were significantly higher in the renal scarring group than in the non-renal scarring group and healthy controls (
P
<0.001). A cutoff value of 6.5 pmol/nmol of urinary C-megalin/Cr yielded 73.9% of specificity and 92.9% of sensitivity.
Conclusion
Urinary C-megalin is useful for diagnosing renal scarring caused by fUTI.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>29211055</pmid><doi>10.1038/pr.2017.276</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Pediatric research, 2018-03, Vol.83 (3), p.662-668 |
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| language | eng |
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| source | Springer Link |
| subjects | 692/4022/1585 692/53/2421 692/699/2768/1865 692/700/1720/3187 Acetylglucosaminidase - urine beta 2-Microglobulin - urine Biomarkers - urine Case-Control Studies Child Child, Preschool Children & youth clinical-investigation Creatinine - urine Fatty Acid-Binding Proteins - urine Female Fever - complications Fever - urine Humans Infant Kidney - diagnostic imaging Kidney - injuries Kidney Diseases - diagnostic imaging Kidney Diseases - etiology Kidney Diseases - urine Kidneys Lipocalin-2 - urine Low Density Lipoprotein Receptor-Related Protein-2 - analysis Male Medicine Medicine & Public Health Pediatric Surgery Pediatrics Proteins Radionuclide Imaging Risk Factors Scars Scintigraphy Sensitivity and Specificity Urinalysis - methods Urinary tract diseases Urinary tract infections Urinary Tract Infections - complications Urinary Tract Infections - urine Urogenital system |
| title | Urinary C-megalin for screening of renal scarring in children after febrile urinary tract infection |
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