Utilization of hypofractionated radiotherapy in treatment of glioblastoma multiforme in elderly patients not receiving adjuvant chemoradiotherapy: A National Cancer Database Analysis

To assess the utilization and outcomes of adjuvant monotherapy with hypofractionated radiation (RT) among elderly patients not receiving traditional adjuvant chemoradiotherapy (cRT) for glioblastoma multiforme (GBM). A retrospective analysis using the National Cancer Data Base with GBM patients aged...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuro-oncology 2018, Vol.136 (2), p.385-394
Main Authors: Bingham, Brian, Patel, Chirayu G., Shinohara, Eric T., Attia, Albert
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Brain cancer
Brain Neoplasms - radiotherapy
Chemoradiotherapy
Chemotherapy
Clinical Study
Databases, Factual
Female
Geriatrics
Glioblastoma
Glioblastoma - radiotherapy
Humans
Kaplan-Meier Estimate
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Neurology
Oncology
Patients
Radiation Dose Hypofractionation
Radiation therapy
Radiotherapy, Adjuvant - statistics & numerical data
Retrospective Studies
Survival analysis
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess the utilization and outcomes of adjuvant monotherapy with hypofractionated radiation (RT) among elderly patients not receiving traditional adjuvant chemoradiotherapy (cRT) for glioblastoma multiforme (GBM). A retrospective analysis using the National Cancer Data Base with GBM patients aged 65 years or older treated between 2005 and 2012 was conducted. Patients who underwent hypofractionated RT (40 Gy), conventional RT (60 Gy), chemotherapy, or best supportive care alone were included. Statistical methods included logistic regression for utilization and Cox regression for survival analysis. A total of 9556 patients were analyzed. On multivariate analysis (compared to those receiving conventional RT), patients more likely to be treated with hypofractionated RT were older (75–84 years old OR 2.05; p  
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-017-2665-8