Cu(II)-Mediated Decarboxylative Trifluoromethylthiolation of α,β-Unsaturated Carboxylic Acids

A tunable method for the direct trifluoromethylthiolation of α,β-unsaturated carboxylic acids was developed to afford trifluoromethylthiolated ketones or alkenes. The reaction proceeds smoothly under mild conditions and shows an excellent functional group tolerance.

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Bibliographic Details
Published in:Journal of organic chemistry 2018-01, Vol.83 (1), p.499-504
Main Authors: Cheng, Zhi-Fei, Tao, Ting-Ting, Feng, Yi-Si, Tang, Wei-Ke, Xu, Jun, Dai, Jian-Jun, Xu, Hua-Jian
Format: Article
Language:English
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Summary:A tunable method for the direct trifluoromethylthiolation of α,β-unsaturated carboxylic acids was developed to afford trifluoromethylthiolated ketones or alkenes. The reaction proceeds smoothly under mild conditions and shows an excellent functional group tolerance.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b02232