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Detrimental Effects of an Antibody Directed Against Tumor Necrosis Factor Alpha in Experimental Kidney Irradiation
Antibodies directed against tumor necrosis factor (TNF)-α are clinically used for Crohn's disease, rheumatoid arthritis and psoriasis. TNF-α is also an important cytokine in radiotherapy because it mediates inflammatory responses in normal tissues. To study the influence of TNF-α inhibition...
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Published in: | Anticancer research 2007-07, Vol.27 (4B), p.2353-2357 |
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creator | NIEDER, Carsten SCHNAITER, Andrea WEBER, Wolfgang A SCHILL, Sabine ANDRATSCHKE, Nicolaus SCHWAIGER, Markus MOLLS, Michael |
description | Antibodies directed against tumor necrosis factor (TNF)-α are clinically used for Crohn's disease, rheumatoid arthritis and
psoriasis. TNF-α is also an important cytokine in radiotherapy because it mediates inflammatory responses in normal tissues.
To study the influence of TNF-α inhibition on radiation toxicity, we used a well-established mouse model of kidney irradiation,
where the portal also includes parts of the intestine. Mice were treated with single-fraction radiotherapy to the right kidney
with doses of 8 or 10 Gy with or without the monoclonal TNF-α antibody infliximab injected i.v. in three doses. The kidney
function was assessed by means of repeated 99m Tc-dimercaptosuccinate scans during a maximum follow-up of 49 weeks. Treatment with infliximab significantly exacerbated radiation
nephropathy at all time points, both in the 8 Gy and 10 Gy groups. The drug itself is not known to cause renal impairment.
In the control group irradiated with 10 Gy, one mouse died from delayed radiation-induced intestinal toxicity. Skin reactions
and general performance status were also similar across the groups. These data suggest that administration of infliximab concomitant
to radiotherapy causes profound alterations in the development of kidney dysfunction. Importantly, other radiation-related
toxicities were similar across all groups. |
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psoriasis. TNF-α is also an important cytokine in radiotherapy because it mediates inflammatory responses in normal tissues.
To study the influence of TNF-α inhibition on radiation toxicity, we used a well-established mouse model of kidney irradiation,
where the portal also includes parts of the intestine. Mice were treated with single-fraction radiotherapy to the right kidney
with doses of 8 or 10 Gy with or without the monoclonal TNF-α antibody infliximab injected i.v. in three doses. The kidney
function was assessed by means of repeated 99m Tc-dimercaptosuccinate scans during a maximum follow-up of 49 weeks. Treatment with infliximab significantly exacerbated radiation
nephropathy at all time points, both in the 8 Gy and 10 Gy groups. The drug itself is not known to cause renal impairment.
In the control group irradiated with 10 Gy, one mouse died from delayed radiation-induced intestinal toxicity. Skin reactions
and general performance status were also similar across the groups. These data suggest that administration of infliximab concomitant
to radiotherapy causes profound alterations in the development of kidney dysfunction. Importantly, other radiation-related
toxicities were similar across all groups.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17695525</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Animals ; Antibodies, Monoclonal - pharmacology ; Antibodies, Monoclonal - toxicity ; Biological and medical sciences ; Female ; Infliximab ; Kidney - drug effects ; Kidney - radiation effects ; Kidney Diseases - chemically induced ; Kidney Diseases - etiology ; Medical sciences ; Mice ; Mice, Inbred C3H ; Miscellaneous ; Radiation Injuries, Experimental - chemically induced ; Radiation Injuries, Experimental - etiology ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor Necrosis Factor-alpha - immunology ; Tumors</subject><ispartof>Anticancer research, 2007-07, Vol.27 (4B), p.2353-2357</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18963360$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17695525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NIEDER, Carsten</creatorcontrib><creatorcontrib>SCHNAITER, Andrea</creatorcontrib><creatorcontrib>WEBER, Wolfgang A</creatorcontrib><creatorcontrib>SCHILL, Sabine</creatorcontrib><creatorcontrib>ANDRATSCHKE, Nicolaus</creatorcontrib><creatorcontrib>SCHWAIGER, Markus</creatorcontrib><creatorcontrib>MOLLS, Michael</creatorcontrib><title>Detrimental Effects of an Antibody Directed Against Tumor Necrosis Factor Alpha in Experimental Kidney Irradiation</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Antibodies directed against tumor necrosis factor (TNF)-α are clinically used for Crohn's disease, rheumatoid arthritis and
psoriasis. TNF-α is also an important cytokine in radiotherapy because it mediates inflammatory responses in normal tissues.
To study the influence of TNF-α inhibition on radiation toxicity, we used a well-established mouse model of kidney irradiation,
where the portal also includes parts of the intestine. Mice were treated with single-fraction radiotherapy to the right kidney
with doses of 8 or 10 Gy with or without the monoclonal TNF-α antibody infliximab injected i.v. in three doses. The kidney
function was assessed by means of repeated 99m Tc-dimercaptosuccinate scans during a maximum follow-up of 49 weeks. Treatment with infliximab significantly exacerbated radiation
nephropathy at all time points, both in the 8 Gy and 10 Gy groups. The drug itself is not known to cause renal impairment.
In the control group irradiated with 10 Gy, one mouse died from delayed radiation-induced intestinal toxicity. Skin reactions
and general performance status were also similar across the groups. These data suggest that administration of infliximab concomitant
to radiotherapy causes profound alterations in the development of kidney dysfunction. Importantly, other radiation-related
toxicities were similar across all groups.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Antibodies, Monoclonal - toxicity</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Infliximab</subject><subject>Kidney - drug effects</subject><subject>Kidney - radiation effects</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - etiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Miscellaneous</subject><subject>Radiation Injuries, Experimental - chemically induced</subject><subject>Radiation Injuries, Experimental - etiology</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LxDAQhoso7rr6FyQXvRXy0aTNse6HLi56Wc9l2qbbSJuuSYruvzfi6sLAMMPDM8N7Fk1JKkmccobPoymmHMcpxnwSXTn3jrEQMmOX0YSkQnJO-TSyC-Wt7pXx0KFl06jKOzQ0CAzKjdflUB_QQtuwVjXKd6CN82g79oNFL6qyg9MOraDyYc67fQtIG7T82qt_57OujTqgtbVQa_B6MNfRRQOdUzfHPoveVsvt_CnevD6u5_kmbhkmPi6Z5KTGOGFClEJKWXJIZEbqMHMu60o0XCSEhcKUqAwwVYIyDFkpWALAZtH9r3dvh49ROV_02lWq68CoYXQFkWlCMykCeHsEx7JXdbEPz4M9FH8pBeDuCICroGssmEq7E_cjYQKfLrZ6136G1ArXQ9cFLSvA0rRIHgrKOGPfakt9pQ</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>NIEDER, Carsten</creator><creator>SCHNAITER, Andrea</creator><creator>WEBER, Wolfgang A</creator><creator>SCHILL, Sabine</creator><creator>ANDRATSCHKE, Nicolaus</creator><creator>SCHWAIGER, Markus</creator><creator>MOLLS, Michael</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20070701</creationdate><title>Detrimental Effects of an Antibody Directed Against Tumor Necrosis Factor Alpha in Experimental Kidney Irradiation</title><author>NIEDER, Carsten ; SCHNAITER, Andrea ; WEBER, Wolfgang A ; SCHILL, Sabine ; ANDRATSCHKE, Nicolaus ; SCHWAIGER, Markus ; MOLLS, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-b3951d004366b6999b5a4981d366559dc6f56413413021e8a02e6230a8b634aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Antibodies, Monoclonal - toxicity</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Infliximab</topic><topic>Kidney - drug effects</topic><topic>Kidney - radiation effects</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - etiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Miscellaneous</topic><topic>Radiation Injuries, Experimental - chemically induced</topic><topic>Radiation Injuries, Experimental - etiology</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NIEDER, Carsten</creatorcontrib><creatorcontrib>SCHNAITER, Andrea</creatorcontrib><creatorcontrib>WEBER, Wolfgang A</creatorcontrib><creatorcontrib>SCHILL, Sabine</creatorcontrib><creatorcontrib>ANDRATSCHKE, Nicolaus</creatorcontrib><creatorcontrib>SCHWAIGER, Markus</creatorcontrib><creatorcontrib>MOLLS, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NIEDER, Carsten</au><au>SCHNAITER, Andrea</au><au>WEBER, Wolfgang A</au><au>SCHILL, Sabine</au><au>ANDRATSCHKE, Nicolaus</au><au>SCHWAIGER, Markus</au><au>MOLLS, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detrimental Effects of an Antibody Directed Against Tumor Necrosis Factor Alpha in Experimental Kidney Irradiation</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>27</volume><issue>4B</issue><spage>2353</spage><epage>2357</epage><pages>2353-2357</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Antibodies directed against tumor necrosis factor (TNF)-α are clinically used for Crohn's disease, rheumatoid arthritis and
psoriasis. TNF-α is also an important cytokine in radiotherapy because it mediates inflammatory responses in normal tissues.
To study the influence of TNF-α inhibition on radiation toxicity, we used a well-established mouse model of kidney irradiation,
where the portal also includes parts of the intestine. Mice were treated with single-fraction radiotherapy to the right kidney
with doses of 8 or 10 Gy with or without the monoclonal TNF-α antibody infliximab injected i.v. in three doses. The kidney
function was assessed by means of repeated 99m Tc-dimercaptosuccinate scans during a maximum follow-up of 49 weeks. Treatment with infliximab significantly exacerbated radiation
nephropathy at all time points, both in the 8 Gy and 10 Gy groups. The drug itself is not known to cause renal impairment.
In the control group irradiated with 10 Gy, one mouse died from delayed radiation-induced intestinal toxicity. Skin reactions
and general performance status were also similar across the groups. These data suggest that administration of infliximab concomitant
to radiotherapy causes profound alterations in the development of kidney dysfunction. Importantly, other radiation-related
toxicities were similar across all groups.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17695525</pmid><tpages>5</tpages></addata></record> |
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subjects | Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - toxicity Biological and medical sciences Female Infliximab Kidney - drug effects Kidney - radiation effects Kidney Diseases - chemically induced Kidney Diseases - etiology Medical sciences Mice Mice, Inbred C3H Miscellaneous Radiation Injuries, Experimental - chemically induced Radiation Injuries, Experimental - etiology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology Tumors |
title | Detrimental Effects of an Antibody Directed Against Tumor Necrosis Factor Alpha in Experimental Kidney Irradiation |
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