FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status

FABP7 expression has been analysed in a series of 123 glioblastomas (68 pure GBM, 55 GBMO, i.e. with oligodendroglial component). FABP7, found in 91/123 samples, showed a pure cytoplasmic expression in 69 cases, and cytoplasmic+nuclear expression in 22 cases. FABP7 expression was associated with pur...

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Bibliographic Details
Published in:Journal of neuro-oncology 2007-09, Vol.84 (3), p.245-248
Main Authors: Kaloshi, Gentian, Mokhtari, Karima, Carpentier, Catherine, Taillibert, Sophie, Lejeune, Julie, Marie, Yannick, Delattre, Jean-Yves, Godbout, Roseline, Sanson, Marc
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - analysis
Brain Neoplasms - metabolism
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Carrier Proteins - biosynthesis
Cell Nucleus - metabolism
Cytoplasm - metabolism
Epidermal growth factor receptors
ErbB Receptors - genetics
ErbB Receptors - metabolism
Fatty Acid-Binding Protein 7
Female
Gene Amplification
Glioblastoma - metabolism
Glioblastoma - mortality
Glioblastoma - pathology
Humans
Kaplan-Meier Estimate
Male
Medical prognosis
Middle Aged
Neoplasm Invasiveness - pathology
Nuclear transport
Prognosis
Protein Transport - physiology
Tumor Suppressor Proteins - biosynthesis
Tumors
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Summary:FABP7 expression has been analysed in a series of 123 glioblastomas (68 pure GBM, 55 GBMO, i.e. with oligodendroglial component). FABP7, found in 91/123 samples, showed a pure cytoplasmic expression in 69 cases, and cytoplasmic+nuclear expression in 22 cases. FABP7 expression was associated with pure GBM histology and shorter survival (15.7 months versus 21.5 months). Nuclear expression of FABP7 was more specifically related to EGFR amplification and more invasive tumors. These data, although they need to be confirmed by further studies, support the relation between FABP7, astrocytic features, invasion and poor prognosis and suggests that EGFR amplification is associated with nuclear translocation of FABP7.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-007-9377-4