Technical aspects of microphysiological systems (MPS) as a promising wet human-in-vivo simulator

Microphysiological systems (MPS) are currently attracting a lot of interest from pharmaceutical companies worldwide. In the United States and European Union, several large government projects related to MPS have been initiated, and, in Japan, pharmaceutical companies interested in MPS are watching t...

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Bibliographic Details
Published in:Drug metabolism and pharmacokinetics 2018-02, Vol.33 (1), p.40-42
Main Authors: Kanamori, Toshiyuki, Sugiura, Shinji, Sakai, Yasuyuki
Format: Article
Language:English
Subjects:
Cell-based assay
iPS cells
Microenvironments
Microfluidics
Organ-specific function
Standardization
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Summary:Microphysiological systems (MPS) are currently attracting a lot of interest from pharmaceutical companies worldwide. In the United States and European Union, several large government projects related to MPS have been initiated, and, in Japan, pharmaceutical companies interested in MPS are watching the recent trends and developments in the field. In July 2017, the Japan Agency for Medical Research and Development initiated a research program to develop chip-based MPS. In this review, we examine the technical aspects of commercializing chip-based MPS.
ISSN:1347-4367
1880-0920
DOI:10.1016/j.dmpk.2017.11.006